Characterization of Thorium-Pyrazinoic acid complexation and its decorporation efficacy in human cells and blood.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2021.129547
Abstract: Thorium (Th) exposure to the human beings is a radiochemical hazard and the chelation therapy by suitable drugs is the major prevention approach to deal with. The present studies aimed at usage of pyrazinoic acid… read more here.
Keywords: pyrazinoic acid; thorium; efficacy; decorporation ... See more keywords
3,2-Hydroxypyridinone-Grafted Chitosan Oligosaccharide Nanoparticles as Efficient Decorporation Agents for Simultaneous Removal of Uranium and Radiation-Induced Reactive Oxygen Species in Vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00711
Abstract: Most of the key radionuclides in the nuclear fuel cycle, such as actinides, possess a combination of heavy metal chemotoxicity and radiotoxicity and therefore represent a severe threat to the ecological environment and public safety.… read more here.
Keywords: uranium; radiation induced; chitosan oligosaccharide; decorporation ... See more keywords
Hinokitiol, an Advanced Bidentate Ligand for Uranyl Decorporation.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.1c03438
Abstract: Despite the critical role actinide decorporation agents play in the emergency treatment of people in nuclear accidents and other scenarios that may cause internal contamination of actinides, new ligands have seldom been reported in recent… read more here.
Keywords: uranyl decorporation; decorporation; hinokitiol advanced; hino ... See more keywords
Carboxylate- and Phosphonate-Modified Polyethylenimine: Toward the Design of Actinide Decorporation Agents.
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.9b02014
Abstract: Plutonium (Pu) is an anthropogenic element involved in the nuclear industry cycle. Located at the bottom of the periodic table within the actinide family, it is a chemical toxic but also a radiological toxic, regardless… read more here.
Keywords: modified polyethylenimine; decorporation; phosphonate modified; polyethylenimine toward ... See more keywords
A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10276-z
Abstract: Searching for actinide decorporation agents with advantages of high decorporation efficiency, minimal biological toxicity, and high oral efficiency is crucial for nuclear safety and the sustainable development of nuclear energy. Removing actinides deposited in bones… read more here.
Keywords: removes uranium; decorporation; hydroxypyridinone based; ligand ... See more keywords
Porous 3D Prussian blue/cellulose aerogel as a decorporation agent for removal of ingested cesium from the gastrointestinal tract
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-22715-w
Abstract: In the present study, we successfully synthesized a porous three-dimensional Prussian blue-cellulose aerogel (PB-CA) composite and used it as a decorporation agent for the selective removal of ingested cesium ions (Cs+) from the gastrointestinal (GI)… read more here.
Keywords: decorporation agent; blue cellulose; tract; decorporation ... See more keywords
Actinide Decorporation: A Review on Chelation Chemistry and Nanocarriers for Pulmonary Administration
Sign Up to like & getrecommendations! Published in 2022 at "Radiation Research"
DOI: 10.1667/rade-21-00004.1
Abstract: Chelation is considered the best method for detoxification by promoting excretion of actinides (Am, Np, Pu, Th, U) from the human body after internal contamination. Chemical agents that possess carboxylic acid or hydroxypyridinonate groups play… read more here.
Keywords: decorporation review; chelation chemistry; chemistry; decorporation ... See more keywords
In Vitro and In Vivo Evaluation of DTPA-HPMA Copolymers as Potential Decorporating Agents for Prophylactic Therapy of Actinide Contamination
Sign Up to like & getrecommendations! Published in 2022 at "Radiation Research"
DOI: 10.1667/rade-21-00244.1
Abstract: The release of actinides into the environment represents a significant potential public health concern. Chelation therapy utilizing diethylenetriamine pentaacetate (DTPA) is a U.S. Food and Drug Administration (FDA)-approved therapy capable of mitigating the deposition of… read more here.
Keywords: vitro; dtpa; decorporation; therapy ... See more keywords
Delivery of DTPA through Liposomes as a Good Strategy for Enhancing Plutonium Decorporation Regardless of Treatment Regimen
Sign Up to like & getrecommendations! Published in 2018 at "Radiation Research"
DOI: 10.1667/rr14968.1
Abstract: In this study, we assessed the efficacy of unilamellar 110-nm liposomes encapsulating the chelating agent diethylenetriaminepentaacetic acid (DTPA) in plutonium-exposed rats. Rats were contaminated by intravenous administration of the soluble citrate form of plutonium. The… read more here.
Keywords: free dtpa; dtpa; treatment; liposomal dtpa ... See more keywords