Simultaneous targeted inhibition of Sox2‐Oct4 transcription factors using decoy oligodeoxynucleotides to repress stemness properties in mouse embryonic stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biology International"
DOI: 10.1002/cbin.10847
Abstract: Transcriptional master regulators like Sox2 and Oct4, which are expressed in various human tumors, have been shown to cause tumor growth promotion as well as epithelial dysplasia by means of interfering with progenitor cell differentiation.… read more here.
Keywords: cell; sox2; stem cells; decoy ... See more keywords
Evaluation of STAT3 decoy oligodeoxynucleotides' synergistic effects on radiation and/or chemotherapy in metastatic breast cancer cell line
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11456
Abstract: Resistance to radiotherapy and chemotherapy has been a major problem of conventional cancer therapies, which consequently leads to cancer relapse and cancer‐related death. It is known that cancer stem cells (CSCs) play a key role… read more here.
Keywords: synergistic effects; breast cancer; cancer; decoy odns ... See more keywords
GlycoNote with Iterative Decoy Searching and Open-Search Component Analysis for High-Throughput and Reliable Glycan Spectral Interpretation.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.3c00083
Abstract: Mass spectrometry-based glycome analysis is a viable strategy for the compositional and functional exploration of glycosylation. However, the lack of generic tools for high-throughput and reliable glycan spectral interpretation largely hampers the broad usability of… read more here.
Keywords: component; decoy; glyconote; interpretation ... See more keywords
A new approach to transfect NF-κB decoy oligodeoxynucleotides into the periodontal tissue using the ultrasound-microbubble method
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Oral Science"
DOI: 10.1038/ijos.2017.10
Abstract: The objective of this study is to investigate the effect of the ultrasound-microbubble technique in nuclear factor kappa B (NF-κB) decoy oligodeoxynucleotide (ODN) transfection in the gingival tissue in mice. The 6-FAM-labeled scrambled decoy ODN… read more here.
Keywords: ultrasound microbubble; periodontal tissue; hum; tissue ... See more keywords
Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats
Sign Up to like & getrecommendations! Published in 2022 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-021-00838-2
Abstract: Myotonic dystrophy type 1 (DM1) is an RNA-dominant disease whose pathogenesis stems from the functional loss of muscleblind-like RNA-binding proteins (RBPs), which causes the formation of alternative-splicing defects. The loss of functional muscleblind-like protein 1… read more here.
Keywords: rna binding; expanded cug; myotonic dystrophy; rna ... See more keywords
Survivability Simulation of Airborne Platform With Expendable Active Decoy Countering RF Missile
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Transactions on Aerospace and Electronic Systems"
DOI: 10.1109/taes.2019.2913722
Abstract: By employing an expendable repeater-type decoy that is known as efficient electronic countermeasure device, the survivability of an airborne platform can be improved. To optimize the survivability of the aircraft by managing the active decoy,… read more here.
Keywords: missile; survivability; platform; airborne platform ... See more keywords
Intratumoral gene transfer of mRNAs encoding interleukin-12 in combination with decoy-resistant interleukin-18 improves local and systemic antitumor immunity.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0373
Abstract: Interleukin-12-based local gene therapy of cancer constitutes an active area of clinical research using plasmids, mRNAs and viral vectors. To improve antitumor effects, we have experimentally tested the combination of mRNA constructs encoding interleukin-12 (IL-12)… read more here.
Keywords: encoding interleukin; antitumor; decoy; intratumoral gene ... See more keywords
Modeling the therapeutic efficacy of NFκB synthetic decoy oligodeoxynucleotides (ODNs)
Sign Up to like & getrecommendations! Published in 2018 at "BMC Systems Biology"
DOI: 10.1186/s12918-018-0525-6
Abstract: BackgroundTransfection of NF κB synthetic decoy Oligodeoxynucleotides (ODNs) has been proposed as a promising therapeutic strategy for a variety of diseases arising from constitutive activation of the eukaryotic transcription factor NF κB. The decoy approach… read more here.
Keywords: synthetic decoy; therapeutic efficacy; biology; decoy ... See more keywords
Inhibitory Effects of STAT3 Transcription Factor by Synthetic Decoy ODNs on Autophagy in Renal Fibrosis
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9040331
Abstract: Autophagy in the proximal tubules may promote fibrosis by activating tubular cell death, interstitial inflammation, and the production of pro-fibrotic factors. The signal transducer and activator of transcription 3 (STAT3) is activated as a potential… read more here.
Keywords: transcription factor; renal fibrosis; fibrosis; decoy ... See more keywords
Anti-Fibrotic Effect of Synthetic Noncoding Decoy ODNs for TFEB in an Animal Model of Chronic Kidney Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158138
Abstract: Despite emerging evidence suggesting that autophagy occurs during renal interstitial fibrosis, the role of autophagy activation in fibrosis and the mechanism by which autophagy influences fibrosis remain controversial. Transcription factor EB (TFEB) is a master… read more here.
Keywords: tfeb decoy; decoy; model; fibrosis ... See more keywords
An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.66831
Abstract: Rationale: Macrophages are the frontline immune cells in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Angiotensin-converting enzyme 2 (ACE2) serves as the binding receptor to SARS-CoV-2 Spike glycoprotein for fusion and internalization… read more here.
Keywords: lenti spike; inflammation; decoy; spike protein ... See more keywords