Regulation of IL-1 signaling by the decoy receptor IL-1R2
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-018-1684-z
Abstract: The pleiotropic cytokine IL-1 mediates its biological functions via association with the signaling receptor IL-1R1. Despite an apparent simplicity in IL-1 signaling activation, multiple negative regulators have been identified. The decoy receptor IL-1R2 (also known… read more here.
Keywords: medicine; receptor 1r2; signaling decoy; regulation signaling ... See more keywords
Decoy receptor targets lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-019-00206-5
Abstract: Human genetic studies have established the orphan G proteincoupled receptor gene, GPR146, as a regulator of plasma cholesterol levels. In line with these findings, Yu et al. report that depletion of GPR146 in mice substantially… read more here.
Keywords: lung cancer; decoy receptor; receptor targets; targets lung ... See more keywords
Decoy receptor 3 down-regulates centrosomal protein 70 kDa specifically in rheumatoid synovial fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Modern Rheumatology"
DOI: 10.1080/14397595.2017.1341593
Abstract: Abstract Objectives: Decoy receptor 3 (DcR3) competitively binds to Fas ligand, lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells (LIGHT) and TNF-like ligand 1A (TL1A), thereby… read more here.
Keywords: protein; decoy receptor; fls; expression ... See more keywords
An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abf1738
Abstract: An engineered decoy receptor tightly binds S from diverse SARS-related coronaviruses with limited potential for viral escape. The spike S of SARS-CoV-2 recognizes ACE2 on the host cell membrane to initiate entry. Soluble decoy receptors,… read more here.
Keywords: cov broadly; receptor sars; engineered decoy; decoy receptor ... See more keywords
A decoy receptor for SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.369.6508.1203-p
Abstract: Coronavirus For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter human cells, the spike protein on the surface of the virus must bind to the host receptor protein, angiotensin-converting enzyme 2 (ACE2). A soluble… read more here.
Keywords: receptor sars; science; decoy receptor; spike protein ... See more keywords
Effect of a Neuropilin-1-Derived Virus Receptor Trap on Enterovirus A71 Infection In Vitro
Sign Up to like & getrecommendations! Published in 2020 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00695-20
Abstract: We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but… read more here.
Keywords: decoy receptor; receptor; nrp1; effect neuropilin ... See more keywords
Interferon α/β Decoy Receptor Encoded by a Variant in the Dryvax Smallpox Vaccine Contributes to Virulence and Correlates with Severe Vaccine Side Effects
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.00102-22
Abstract: Attenuated live viruses make effective vaccines, although concerns exist due to infrequent complications, particularly in individuals with immunological defects. Such complications occurred with smallpox vaccines, which were shown to be comprised of populations of variants.… read more here.
Keywords: receptor; smallpox vaccine; decoy receptor;
Abstract 708: Characterization of MDNA132, an IL-13 decoy receptor selective superkine for targeted delivery of immunotherapies to the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-708
Abstract: Background: Interleukin-13 (IL-13) exhibits high affinity for the IL-13 decoy receptor (IL13Rα2) but retains binding to IL13α1, a component of the functional Type II IL4R complex (IL4Rα/IL13Rα1) that elicits a Th2 immune response. IL13Rα2 expression… read more here.
Keywords: il13r; anti pd1; mdna132; decoy receptor ... See more keywords
Effluent decoy receptor 2 as a novel biomarker of peritoneal fibrosis in peritoneal dialysis patients
Sign Up to like & getrecommendations! Published in 2022 at "Peritoneal Dialysis International"
DOI: 10.1177/08968608211067866
Abstract: Background: Peritoneal fibrosis (PF) is a common complication of peritoneal dialysis (PD), but a specific and sensitive biomarker for PF is lacking. The present study aimed to determine the use of effluent decoy receptor 2… read more here.
Keywords: peritoneal fibrosis; biomarker; peritoneal dialysis; decoy receptor ... See more keywords
Anti-tumor activity of a recombinant soluble Fzd7 decoy receptor in human gastric and colon cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.61908.13700
Abstract: Objective(s): Frizzled-7, the most common receptor of the Wnt signaling pathway, was significantly over-expressed in gastric (GC) and colorectal (CRC) cancers and stimulated tumorigenesis. The extracellular domain of Fzd7 (sFzd7) as a decoy receptor, could… read more here.
Keywords: fzd7; colon cancer; decoy receptor; receptor ... See more keywords
Decoy Receptor 3 Suppresses T-Cell Priming and Promotes Apoptosis of Effector T-Cells in Acute Cell-Mediated Rejection: The Role of Reverse Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.879648
Abstract: Background Decoy receptor 3 (DcR3) belongs to the tumor necrosis factor (TNF) receptor superfamily and neutralizes TNF ligands, including FasL and TRAIL, to prevent T activation during T-cell priming. However, the cellular mechanisms underlying acute… read more here.
Keywords: cell; dcr3; acute cell; cell priming ... See more keywords