δ-Globin Chain Variants Associated with Decreased Hb A2 Levels: A National Reference Laboratory Experience
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DOI: 10.1080/03630269.2020.1831531
Abstract: Abstract High prevalence of hemoglobin (Hb) disorders mandates national programs for screening and genetic counseling in many countries. Increased Hb A2 levels are commonly associated with β-thalassemias, however, various disorders including alteration of δ chains… read more here.
Keywords: globin chain; experience; decreased levels; reference laboratory ... See more keywords
Senkyunolide A inhibits the progression of osteoarthritis by inhibiting the NLRP3 signalling pathway
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DOI: 10.1080/13880209.2022.2042327
Abstract: Abstract Context Osteoarthritis (OA) is a degenerative disease. Senkyunolide A (SenA) is an important phthalide from Ligusticum chuanxiong Hort (Umbelliferae) with anti-spasmodic and neuroprotective effects. Objective We explored the effect of SenA on IL-1β-stimulated chondrocytes… read more here.
Keywords: inhibits progression; progression; inhibiting nlrp3; nlrp3 signalling ... See more keywords
Decreased Levels of Vitamin D in Bipolar Patients
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DOI: 10.3390/life13040883
Abstract: Recently, vitamin D is considered a pleiotropic hormone, and as such, it has also become a topic of renewed interest in neuropsychiatry for its proposed role in the aetiology and pathophysiology of different psychiatric conditions,… read more here.
Keywords: vitamin levels; bipolar patients; vitamin bipolar; levels vitamin ... See more keywords
Decreased Levels of Chaperones in Mucopolysaccharidoses and Their Elevation as a Putative Auxiliary Therapeutic Approach
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DOI: 10.3390/pharmaceutics15020704
Abstract: Mucopolysaccharidoses (MPS) are rare genetic disorders belonging to the lysosomal storage diseases. They are caused by mutations in genes encoding lysosomal enzymes responsible for degrading glycosaminoglycans (GAGs). As a result, GAGs accumulate in lysosomes, leading… read more here.
Keywords: mucopolysaccharidoses elevation; levels chaperones; elevation putative; chaperones mucopolysaccharidoses ... See more keywords