Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity.
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DOI: 10.1016/j.mito.2017.08.001
Abstract: Humanin (HN) is an endogenous peptide that exerts cytoprotection against oxidative stress and apoptosis. We recently reported that Humanin analogue (HNG) pretreatment can reduce reactive oxygen species production in the heart subjected to ischemia/reperfusion (I/R)… read more here.
Keywords: oxidative stress; decreasing complex; stress; complex activity ... See more keywords