Mammalian Target of Rapamycin Complex 1 Signaling Is Required for the Dedifferentiation From Biliary Cell to Bipotential Progenitor Cell in Zebrafish Liver Regeneration
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30790
Abstract: The liver has a high regenerative capacity. Upon two‐thirds partial hepatectomy, the hepatocytes proliferate and contribute to liver regeneration. After severe liver injury, when the proliferation of residual hepatocytes is blocked, the biliary epithelial cells… read more here.
Keywords: liver regeneration; dedifferentiation; cell; proliferation ... See more keywords
SIRT6 Negatively Regulates Schwann Cells Dedifferentiation via Targeting c-Jun During Wallerian Degeneration After Peripheral Nerve Injury.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02607-3
Abstract: Silent information regulator 6 (SIRT6) is a mammalian homolog of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin family. Previous studies have been reported a pro-regenerative role of SIRT6 in central nervous system injury. However, the… read more here.
Keywords: sirt6; dedifferentiation; injury; nerve ... See more keywords
Extracellular matrix derived from chondrocytes promotes rapid expansion of human primary chondrocytes in vitro with reduced dedifferentiation.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.12.006
Abstract: A significant expansion of autologous chondrocytes in vitro is required for cell-based cartilage repair. However, the in vitro expansion of chondrocytes under standard culture conditions inevitably leads to the dedifferentiation of chondrocytes and contributes to… read more here.
Keywords: expansion; microscopy; vitro expansion; chondrocytes vitro ... See more keywords
Dedifferentiation alters chondrocyte nuclear mechanics during in vitro culture and expansion.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.11.018
Abstract: The biophysical features of a cell can provide global insights into diverse molecular changes, especially in processes like the dedifferentiation of chondrocytes. Key biophysical markers of chondrocyte dedifferentiation include flattened cellular morphology and increased stress-fiber… read more here.
Keywords: nuclear mechanics; expansion; strain; dedifferentiation ... See more keywords
Dedifferentiation of radial glia-like cells is observed in in vitro explants of holothurian radial nerve cord
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2021.109358
Abstract: BACKGROUND Among animal phyla, some of the least studied nervous systems are those of the phylum Echinodermata. Part of the problem lies in that most of their nervous components are embedded in the body wall… read more here.
Keywords: radial glia; glia like; dedifferentiation radial; radial nerve ... See more keywords
Modeling human pancreatic beta cell dedifferentiation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.02.002
Abstract: Objective Dedifferentiation could explain reduced functional pancreatic β-cell mass in type 2 diabetes (T2D). Methods Here we model human β-cell dedifferentiation using growth factor stimulation in the human β-cell line, EndoC-βH1, and human pancreatic islets.… read more here.
Keywords: fgf2; cell dedifferentiation; human pancreatic; expression ... See more keywords
Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.101057
Abstract: Objective Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes (T2D). However, the prevalence, plasticity and functional consequences of this cellular state remain unknown. Methods We employed single-cell RNAseq to detail the… read more here.
Keywords: single cell; islet; program; dedifferentiation ... See more keywords
Dedifferentiation of Epithelial Cells Incorporates Immune Reprogramming.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2021.01.007
Abstract: Recent innovations in immunotherapies have cured cancers but remain ineffective in pancreatic cancer, which exhibits intertwined dynamics of dedifferentiation of epithelium and reprogramming ofimmunosuppression. Emerging evidence reveals the biological mechanisms through which dedifferentiation recapitulates immune… read more here.
Keywords: epithelial cells; immune reprogramming; cells incorporates; incorporates immune ... See more keywords
Single-cell imaging and transcriptomic analyses of endogenous cardiomyocyte dedifferentiation and cycling
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DOI: 10.1038/s41421-019-0095-9
Abstract: While it is recognized that there are low levels of new cardiomyocyte (CM) formation throughout life, the source of these new CM generates much debate. One hypothesis is that these new CMs arise from the… read more here.
Keywords: single cell; cell imaging; cms; dedifferentiation ... See more keywords
Increased Fat Graft Survival By Promoting Adipocyte Dedifferentiation.
Sign Up to like & getrecommendations! Published in 2022 at "Aesthetic surgery journal"
DOI: 10.1093/asj/sjac296
Abstract: BACKGROUND Some adipocytes undergo dedifferentiation after fat transplantation, and this may affect the survival of fat grafts. However, this has not been adequately studied. OBJECTIVES This study aimed to clarify the effect of promoting the… read more here.
Keywords: dedifferentiation mature; survival; dedifferentiation; group ... See more keywords
Age differences in the functional architecture of the human brain.
Sign Up to like & getrecommendations! Published in 2022 at "Cerebral cortex"
DOI: 10.1093/cercor/bhac056
Abstract: The intrinsic functional organization of the brain changes into older adulthood. Age differences are observed at multiple spatial scales, from global reductions in modularity and segregation of distributed brain systems, to network-specific patterns of dedifferentiation.… read more here.
Keywords: network; age differences; brain; dedifferentiation ... See more keywords