Development and physicochemical characterization of acetalated dextran aerosol particle systems for deep lung delivery.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.04.052
Abstract: Biocompatible, biodegradable polymers are commonly used as excipients to improve the drug delivery properties of aerosol formulations, in which acetalated dextran (Ac-Dex) exhibits promising potential as a polymer in various therapeutic applications. Despite this promise,… read more here.
Keywords: dex; deep lung; delivery; drug ... See more keywords
Towards whole-lung simulations of aerosol deposition: A model of the deep lung
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Aerosol Science"
DOI: 10.1016/j.jaerosci.2020.105541
Abstract: Abstract In silico methods can be used to estimate regional deposition of inhaled aerosols in regions of the lung that are inaccessible by direct measurements. Knowledge of deposited dose is important for assessing the efficacy… read more here.
Keywords: deep lung; model deep; deposition; whole lung ... See more keywords
Pores of Kohn: forgotten alveolar structures and potential source of aerosols in exhaled breath.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of breath research"
DOI: 10.1088/1752-7163/ab0524
Abstract: Analysis of human and animal exhaled breath has identified numerous compounds including proteins and surfactant constituents from the deep lung. Some mechanisms such as coughing, breaking of surfactant/mucus plugs, or 'bronchiole film bursting' have been… read more here.
Keywords: breath; deep lung; exhaled breath; film ... See more keywords
Inhalation of virus-loaded droplets as a clinically plausible pathway to deep lung infection
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1073165
Abstract: Respiratory viruses, such as SARS-CoV-2, preliminarily infect the nasopharyngeal mucosa. The mechanism of infection spread from the nasopharynx to the deep lung–which may cause a severe infection—is, however, still unclear. We propose a clinically plausible… read more here.
Keywords: infection; clinically plausible; lung infection; virus ... See more keywords