Biodegradable Nanocomposite with Dual Cell-Tissue Penetration for Deep Tumor Chemo-Phototherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Small"
DOI: 10.1002/smll.202000809
Abstract: Chemo-phototherapy, as a promising cancer combination therapy strategy, has attracted widespread attention. However, the complex tumor microenvironment restricts the penetration depth of chemo-phototherapy agents in the tumor region. Here, biodegradable amphiphilic gelatin (AG) wrapped nanocomposite… read more here.
Keywords: chemo phototherapy; deep tumor; chemo; penetration ... See more keywords
Dual pH/ROS-Responsive Nanoplatform with Deep Tumor Penetration and Self-Amplified Drug Release for Enhancing Tumor Chemotherapeutic Efficacy.
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DOI: 10.1002/smll.202002188
Abstract: Poor deep tumor penetration and incomplete intracellular drug release remain challenges for antitumor nanomedicine application in clinical settings. Herein, a nanomedicine (RLPA-NPs) is developed that can achieve prolonged blood circulation, deep tumor penetration, active-targeting of… read more here.
Keywords: tumor penetration; drug; deep tumor; rlpa nps ... See more keywords
Deep Tumor Penetrating Gold Nano-Adjuvant for NIR-II-Triggered In Situ Tumor Vaccination.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202200993
Abstract: Local tumor photothermal treatment with the near-infrared light at the second window (NIR-II) is a promising strategy in triggering the in situ tumor vaccination (ISTV) for cancer therapy. However, limited penetration of photothermal agents within… read more here.
Keywords: deep tumor; nano adjuvant; tumor vaccination; situ tumor ... See more keywords
NIR powered Janus nanocarrier for deep tumor penetration
Sign Up to like & getrecommendations! Published in 2020 at "Applied Materials Today"
DOI: 10.1016/j.apmt.2019.100504
Abstract: Abstract To improve the utilization and achieve deep tumor penetration of nanocarriers, we developed a Janus nanocarrier by simply sputter Au on a mesoporous silica nanocarrier. Such Janus nanocarrier with an Au surface that could… read more here.
Keywords: janus nanocarrier; tumor penetration; nir powered; deep tumor ... See more keywords
Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.03.046
Abstract: Chemotherapy remains restricted by poor drug delivery efficacy due to the heterogenous nature of tumor. Herein, we presented a novel nanoparticle that could not only response to the tumor microenvironment but also modulate it for… read more here.
Keywords: tumor penetration; laser; penetration combination; penetration ... See more keywords
Enhanced Bax upregulating in mitochondria for deep tumor therapy based on SO2 prodrug loaded Au-Ag hollow nanotriangles.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120076
Abstract: Nowadays, limited deep tumor penetration and lower therapeutic effect are still the major obstacle in nanomedicines for cancer therapy. Here, we developed high-efficiency nanocomposites, SO2 prodrug (BTS) loaded Au-Ag hollow nanotriangles (Au-Ag-BTS HTNs), which could… read more here.
Keywords: hollow nanotriangles; so2 prodrug; tumor therapy; deep tumor ... See more keywords
Ultrasmall platinum nanoparticles enable deep tumor penetration and synergistic therapeutic abilities through free radical species-assisted catalysis to combat cancer multidrug resistance
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2019.123138
Abstract: Abstract Despite the significant advancements in the development of a wide-variety of nanocarriers-based delivery systems for cancer therapy, several predominant issues remain unaddressed such as active combat of cancer multidrug resistance (MDR) and the limited… read more here.
Keywords: tumor penetration; penetration; free radical; deep tumor ... See more keywords
Deep tumor‐penetrated nanosystem eliminates cancer stem cell for highly efficient liver cancer therapy
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2020.127874
Abstract: Abstract Cancer stem cells (CSCs), which are resistant to the traditional therapies, have been considered to account for the development, metastasis, and relapse of various malignant tumors, and therefore, must be eliminated to cure cancer.… read more here.
Keywords: cancer stem; deep tumor; cancer; cancer therapy ... See more keywords
Re-excision of deep tumor: Width is as important as depth.
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DOI: 10.1016/j.jaad.2016.11.023
Abstract: SURGICAL CHALLENGE Facedwith a positive deep histologic margin, a common error is to focus the re-excision solely on achieving a depth greater than that of the first attempt. Viewing the wound from the surface, with… read more here.
Keywords: depth; excision; excision deep; base ... See more keywords
A Two-Pronged Strategy for Enhanced Deep-Tumor Penetration and NIR-II Multimodal Imaging-Monitored Photothermal Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c08930
Abstract: The second near-infrared (NIR-II)-induced photothermal therapy (PTT) has attracted a great deal of attention in recent years due to its non-invasiveness and because it uses less energy. However, the penetration of photothermal agents into solid… read more here.
Keywords: pronged strategy; photothermal therapy; nir multimodal; two pronged ... See more keywords
Enzyme-Triggered Size-Switchable Nanosystem for Deep Tumor Penetration and Hydrogen Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c18184
Abstract: The poor penetration of nanocarriers within tumor dense extracellular matrices (ECM) greatly restricts the access of anticancer drugs to the deep tumor cells, resulting in low therapeutic efficacy. Moreover, the high toxicity of the traditional… read more here.
Keywords: therapy; tumor penetration; size; tumor ... See more keywords