The Non‐Peptide Vasopressin V1b Receptor Antagonist, SSR149415, Ameliorates Spermatogenesis Function in a Mouse Model of Chronic Social Defeat Stress
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DOI: 10.1002/jcb.26040
Abstract: To determine the effects of SSR149415 on testis and spermatogenesis in male mice subjected to chronic social defeat stress, C57BL/6 male mice were divided into two groups: Control and Stress. Then Stress group was subdivided… read more here.
Keywords: social defeat; defeat stress; stress; chronic social ... See more keywords
Lack of dopamine D1 receptors in the antidepressant actions of (R)-ketamine in a chronic social defeat stress model
Sign Up to like & getrecommendations! Published in 2019 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-019-01012-1
Abstract: It is reported that dopamine D 1 receptors in the medial prefrontal cortex play a role in the antidepressant actions of ( R,S )-ketamine. However, its role in the antidepressant actions of ( R )-ketamine,… read more here.
Keywords: social defeat; antidepressant actions; dopamine receptors; defeat stress ... See more keywords
Chronic vicarious social defeat stress attenuates new-born neuronal cell survival in mouse hippocampus
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DOI: 10.1016/j.bbr.2021.113536
Abstract: Increasing evidence has shown that adult hippocampal neurogenesis is closely related to the pathophysiological condition of depressive disorders. Recently, chronic social defeat stress paradigms have been regarded as important animal models of depression, accompanied with… read more here.
Keywords: social defeat; cell survival; defeat stress; stress ... See more keywords
Computational Analysis of Multidimensional Behavioral Alterations After Chronic Social Defeat Stress
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DOI: 10.1016/j.biopsych.2020.10.010
Abstract: BACKGROUND The study of depression in humans depends on animal models that attempt to mimic specific features of the human syndrome. Most studies focus on one or a few behavioral domains, with time and practical… read more here.
Keywords: social defeat; analysis; defeat stress; behavioral alterations ... See more keywords
Metabolite signature associated with stress susceptibility in socially defeated mice
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DOI: 10.1016/j.brainres.2018.12.020
Abstract: OBJECTIVE Social defeat represents a naturalistic form of conditioned fear and is often used as an animal model of depression. The present study aimed to identify the neurochemicals in select brain regions of mice exposed… read more here.
Keywords: social defeat; susceptibility; defeat stress; mice ... See more keywords
Hippocampal overexpression of chordin protects against the chronic social defeat stress-induced depressive-like effects in mice
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.02.010
Abstract: Depression is a serious and worldwide neuropsychiatric disesase, and developing novel antidepressant targets beyond the monoaminergic systems is now popular and necessary. Bone morphogenetic protein (BMP) signals modulate numerous developmental, physiological, and homeostatic processes. The… read more here.
Keywords: induced depressive; chordin; social defeat; defeat stress ... See more keywords
Repeated social defeat stress inhibits development of hippocampus neurons through mitophagy and autophagy
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DOI: 10.1016/j.brainresbull.2022.01.009
Abstract: The social defeat stress model is commonly used to study depression and anxiety disorder, which can significantly affect the structure and function of neurons in the hippocampus; however, the relevant mechanism in neuronal loss has… read more here.
Keywords: social defeat; mitophagy autophagy; development; defeat stress ... See more keywords
Brain-derived neurotrophic factor signaling plays a role in resilience to stress promoted by isoquinoline in defeated mice.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2017.06.012
Abstract: Certain stressful life events have been associated with the onset of depression. This study aims to investigate if 7-fluoro-1,3-diphenylisoquinoline-1-amine (FDPI) is effective against social avoidance induced by social defeat stress model in mice. Furthermore, it… read more here.
Keywords: social defeat; stress mice; defeat stress; stress ... See more keywords
Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117669
Abstract: Chronic social defeat stress (CSDS) is an ethologically relevant psychosocial stress animal model and has been widely used in depression studies. Ginsenoside Rg1 (Rg1) is the major active ingredients of ginseng with low toxicity and… read more here.
Keywords: social defeat; rg1; defeat stress; depressive like ... See more keywords
Social defeat stress-induced hyperalgesia is mediated by nav 1.8+ nociceptive fibers
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DOI: 10.1016/j.neulet.2020.135006
Abstract: Recently the voltage-gated sodium (Nav) channels began to be studied as possible targets for analgesic drugs. In addition, specific Nav 1.8 blockers are currently being used to treat some types of chronic pain pathologies such… read more here.
Keywords: social defeat; nociceptive fibers; hyperalgesia; defeat stress ... See more keywords
Lateral hypothalamus orexinergic inputs to lateral habenula modulate maladaptation after social defeat stress
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2021.100298
Abstract: Social stress, a common stressor, causes multiple forms of physical and mental dysfunction. Prolonged exposure to social stress is associated with a higher risk of psychological disorders, including anxiety disorders and major depressive disorder (MDD).… read more here.
Keywords: social defeat; chronic social; lateral habenula; defeat stress ... See more keywords