Articles with "defective autophagy" as a keyword



#736 Defective autophagy drives ferroptosis via mitochondrial ROS in diabetic kidney disease

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Published in 2025 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfaf116.0996

Abstract: Ferroptosis is a regulated form of cell death triggered by excessive lipid peroxidation and plays a crucial role in the pathogenesis of acute kidney injury (AKI). While autophagy has been shown to drive ferroptotic cell… read more here.

Keywords: mice; defective autophagy; ferroptosis; injury ... See more keywords

IL-17 Induces Autophagy Dysfunction to Promote Inflammatory Cell Death and Fibrosis in Keloid Fibroblasts via the STAT3 and HIF-1α Dependent Signaling Pathways

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Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.888719

Abstract: Keloid is an abnormal fibrotic disease after cutaneous injury characterized by exaggerated scar tissue formation, which often extends beyond the boundaries of the original wound. Although chronic inflammation is known to be associated with the… read more here.

Keywords: stat3 hif; fibrosis; keloid; defective autophagy ... See more keywords