Defective Interfering Viral Particle Treatment Reduces Clinical Signs and Protects Hamsters from Lethal Nipah Virus Disease
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DOI: 10.1128/mbio.03294-21
Abstract: Here, we demonstrate that treatment with defective interfering particles (DIs), a natural by-product of viral infection, can significantly improve the clinical course and outcome of viral disease. When present with their parental virus, DIs can… read more here.
Keywords: defective interfering; disease; virus disease; nipah virus ... See more keywords
Defective Interfering Particles with Broad-Acting Antiviral Activity for Dengue, Zika, Yellow Fever, Respiratory Syncytial and SARS-CoV-2 Virus Infection
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DOI: 10.1128/spectrum.03949-22
Abstract: DIPs are spontaneously derived virus mutants with deletions in genes that block viral replication. DIPs play important roles in modulation of viral disease, innate immune responses, virus persistence and virus evolution. ABSTRACT More than 100… read more here.
Keywords: defective interfering; interfering particles; yellow fever; respiratory syncytial ... See more keywords
sgDI-tector: defective interfering viral genome bioinformatics for detection of coronavirus subgenomic RNAs
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DOI: 10.1261/rna.078969.121
Abstract: Coronavirus RNA-dependent RNA polymerases produce subgenomic RNAs (sgRNAs) that encode viral structural and accessory proteins. User-friendly bioinformatic tools to detect and quantify sgRNA production are urgently needed to study the growing number of next-generation sequencing… read more here.
Keywords: defective interfering; subgenomic rnas; detection; interfering viral ... See more keywords
Defective Interfering Particles of Influenza Virus and Their Characteristics, Impacts, and Use in Vaccines and Antiviral Strategies: A Systematic Review
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DOI: 10.3390/v14122773
Abstract: Defective interfering particles (DIPs) are particles containing defective viral genomes (DVGs) generated during viral replication. DIPs have been found in various RNA viruses, especially in influenza viruses. Evidence indicates that DIPs interfere with the replication… read more here.
Keywords: defective interfering; antiviral strategies; particles influenza; virus dips ... See more keywords