Different configurations of SARS-CoV-2 spike protein delivered by integrase-defective lentiviral vectors induce persistent functional immune responses, characterized by distinct immunogenicity profiles
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1147953
Abstract: Several COVID-19 vaccine strategies utilizing new formulations for the induction of neutralizing antibodies (nAbs) and T cell immunity are still under evaluation in preclinical and clinical studies. Here we used Simian Immunodeficiency Virus (SIV)-based integrase… read more here.
Keywords: defective lentiviral; immunogenicity; spike protein; integrase defective ... See more keywords
Integrase-Defective Lentiviral Vectors for Delivery of Monoclonal Antibodies against Influenza
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DOI: 10.3390/v12121460
Abstract: Delivering rapid protection against infectious agents to non-immune populations is a formidable public health challenge. Although passive immunotherapy is a fast and effective method of protection, large-scale production and administration of monoclonal antibodies (mAbs) is… read more here.
Keywords: integrase defective; protection; administration; monoclonal antibodies ... See more keywords
Integrase-Defective Lentiviral Vector Is an Efficient Vaccine Platform for Cancer Immunotherapy
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DOI: 10.3390/v13020355
Abstract: Integrase-defective lentiviral vectors (IDLVs) have been used as a safe and efficient delivery system in several immunization protocols in murine and non-human primate preclinical models as well as in recent clinical trials. In this work,… read more here.
Keywords: integrase defective; defective lentiviral; vaccine platform; cancer immunotherapy ... See more keywords