Brugada syndrome trafficking-defective Nav1.5 channels can trap cardiac Kir2.1/2.2 channels.
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DOI: 10.1172/jci.insight.96291
Abstract: Cardiac Nav1.5 and Kir2.1-2.3 channels generate Na (INa) and inward rectifier K (IK1) currents, respectively. The functional INa and IK1 interplay is reinforced by the positive and reciprocal modulation between Nav15 and Kir2.1/2.2 channels to… read more here.
Keywords: kir2 channels; nav1 channels; defective nav1; trafficking defective ... See more keywords