A defective viral genome strategy elicits broad protective immunity against respiratory viruses
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.11.023
Abstract: RNA viruses generate defective viral genomes (DVG) that can interfere with replication of the parental wild-type virus. To examine their therapeutic potential, we created a DVG by deleting the capsid-coding region of poliovirus. Strikingly, intraperitoneal… read more here.
Keywords: genome strategy; defective viral; strategy elicits; sars cov ... See more keywords
In Vivo Generation of BK and JC Polyomavirus Defective Viral Genomes in Human Urine Samples Associated with Higher Viral Loads
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.00250-21
Abstract: Defective viral genomes (DVGs) can have a significant impact on the production of infectious virus particles. DVGs have only been identified in cultured viruses passaged at high multiplicities of infection and RNA viruses collected from… read more here.
Keywords: dvgs; viral genomes; clinical specimens; defective viral ... See more keywords
Identification and Characterization of Defective Viral Genomes in Ebola Virus-Infected Rhesus Macaques
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.00714-21
Abstract: The study of filovirus pathogenesis is critical for understanding the consequences of infection and for the development of strategies to ameliorate future outbreaks. Defective viral genomes (DVGs) have been detected during EBOV infections in vitro;… read more here.
Keywords: presence; dvgs; viral genomes; infection ... See more keywords
Generation and Functional Analysis of Defective Viral Genomes during SARS-CoV-2 Infection
Sign Up to like & getrecommendations! Published in 2023 at "mBio"
DOI: 10.1128/mbio.00250-23
Abstract: Defective viral genomes (DVGs) are generated ubiquitously in many RNA viruses, including SARS-CoV-2. Their interference activity to full-length viruses and IFN stimulation provide the potential for them to be used in novel antiviral therapies and… read more here.
Keywords: defective viral; generation; cov infection; viral genomes ... See more keywords
Safety, Immunogenicity, and Effectiveness of Defective Viral Particles Arising in Mast Cells Against Influenza in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.585254
Abstract: Mast cells play pivotal roles in the pathogenesis of influenza A virus (IAV) infections. Defective viral particles (DPs) often arise during IAV replication, which can interfere with the replication of infectious viruses and stimulate the… read more here.
Keywords: arising mast; mast cells; mast; defective viral ... See more keywords