Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120090
Abstract: Basement membranes (BMs) are specialised extracellular matrices that provide structural support to tissues as well as influence cell behaviour and signalling. Mutations in COL4A1/COL4A2, a major BM component, cause a familial form of eye, kidney… read more here.
Keywords: matrix defects; driven fibronectin; fibronectin assembly; material driven ... See more keywords
OXPHOS Defects Due to mtDNA Mutations: Glutamine to the Rescue!
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.05.010
Abstract: Mutations in mtDNA associated with OXPHOS defects preclude energy harnessing by OXPHOS. The work of Chen et al. (2018) is previewed, reporting flux pathways of glutamine catabolism in mtDNA mutant cells yielding high-energy phosphates through substrate-level… read more here.
Keywords: glutamine rescue; due mtdna; defects due; oxphos defects ... See more keywords