Meiotic defects in human oocytes: Potential causes and clinical implications
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DOI: 10.1002/bies.202200135
Abstract: Meiotic defects cause abnormal chromosome segregation leading to aneuploidy in mammalian oocytes. Chromosome segregation is particularly error‐prone in human oocytes, but the mechanisms behind such errors remain unclear. To explain the frequent chromosome segregation errors,… read more here.
Keywords: chromosome segregation; defects human; meiotic defects; human oocytes ... See more keywords
O-067 Biallelic variants in DLGAP5 cause spindle assembly defects and human early embryonic arrest
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DOI: 10.1093/humrep/deaf097.067
Abstract: What effects do DLGAP5 defects have on human early embryo development? DLGAP5 deficiency disrupts normal spindle assembly through its interaction with TACC3, resulting in female infertility characterized as recurrent early embryonic arrest (REEA). REEA is… read more here.
Keywords: human early; defects human; spindle assembly; early embryonic ... See more keywords