Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes.
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DOI: 10.1182/blood.2022016783
Abstract: The mechanisms of coordinated changes in proteome composition and their relevance for the differentiation of neutrophil granulocytes are not well studied. Here, we discover two novel human genetic defects in SRPRA and SRP19, constituents of… read more here.
Keywords: defects srp19; human genetic; genetic defects; neutrophil granulocytes ... See more keywords