Calorimetry Methods to Study Membrane Interactions and Perturbations Induced by Antimicrobial Host Defense Peptides.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6737-7_9
Abstract: Biological membranes play an important role in determining the activity and selectivity of antimicrobial host defense peptides (AMPs). Several biophysical methods have been developed to study the interactions of AMPs with biological membranes. Isothermal titration… read more here.
Keywords: methods study; defense peptides; host defense; membrane interactions ... See more keywords
A defective release of host defense peptides is present in canine atopic skin.
Sign Up to like & getrecommendations! Published in 2019 at "Comparative immunology, microbiology and infectious diseases"
DOI: 10.1016/j.cimid.2019.04.008
Abstract: The use of dogs as animal model for human atopic dermatitis (AD) is well known. Striking similarities in the pathogenesis of AD have been demonstrated. Similar alteration of host defense peptides (HDP) have been identified… read more here.
Keywords: host defense; defense peptides; skin; atopic ... See more keywords
LC-MS/MS assay coupled with carboxylic acid magnetic bead affinity capture to quantitatively measure cationic host defense peptides (HDPs) in complex matrices with application to preclinical pharmacokinetic studies.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113093
Abstract: Synthetic host defense peptides (HDP) are a new class of promising therapeutic agents with potential application in a variety of diseases. RP-182 is a 10mer synthetic HDP design, which selectively reduces M2-like tumor associated macrophages… read more here.
Keywords: acid magnetic; defense; defense peptides; carboxylic acid ... See more keywords
Antimicrobial and immunomodulatory activity of host defense peptides, clavanins and LL-37, in vitro: An endodontic perspective
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DOI: 10.1016/j.peptides.2017.07.005
Abstract: &NA; Endodontic treatment is mainly based on root canal disinfection and its failure may be motivated by microbial resistance. Endodontic therapy can be benefitted by host defense peptides (HDPs), which are multifunctional molecules that act… read more here.
Keywords: production; agr; tnf agr; defense peptides ... See more keywords
Long-term exposure to particulate matter from air pollution alters airway β-defensin-3 and -4 and cathelicidin host defense peptides production in a murine model
Sign Up to like & getrecommendations! Published in 2021 at "Peptides"
DOI: 10.1016/j.peptides.2021.170581
Abstract: Epidemiological studies have associated long-term exposure to environmental air pollution particulate matter (PM) with the development of diverse health problems. They include infectious respiratory diseases related to the deregulation of some innate immune response mechanisms,… read more here.
Keywords: long term; exposure; defense peptides; host defense ... See more keywords
Novel Defense Peptides from Platelets Kill Malaria Parasites.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in parasitology"
DOI: 10.1016/j.pt.2018.07.013
Abstract: PF4 (platelet factor 4) is the first host defense peptide identified from platelets that kills malaria parasites. In a recent study, a cyclic PF4 derivative, cPF4PD, is developed, which inherits the antiparasitic effect of PF4… read more here.
Keywords: defense; novel defense; defense peptides; malaria parasites ... See more keywords
Tuneable poration: host defense peptides as sequence probes for antimicrobial mechanisms
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33289-y
Abstract: The spread of antimicrobial resistance stimulates discovery strategies that place emphasis on mechanisms circumventing the drawbacks of traditional antibiotics and on agents that hit multiple targets. Host defense peptides (HDPs) are promising candidates in this… read more here.
Keywords: antimicrobial mechanisms; defense peptides; poration; host defense ... See more keywords
Interplay between membrane active host defense peptides and heme modulates their assemblies and in vitro activity
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DOI: 10.1038/s41598-021-97779-2
Abstract: In the emerging era of antimicrobial resistance, the susceptibility to co-infections of patients suffering from either acquired or inherited hemolytic disorders can lead to dramatic increase in mortality rates. Closely related, heme liberated during hemolysis… read more here.
Keywords: defense peptides; host; host defense; membrane ... See more keywords
Outer Membrane Vesicles Protect Gram-Negative Bacteria against Host Defense Peptides
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DOI: 10.1128/msphere.00523-21
Abstract: Antibiotic resistance is a pressing problem and estimated to be a leading cause of mortality by 2050. Antimicrobial peptides, also known as host defense peptides (HDPs), and HDP-derived antimicrobials have potent antimicrobial activity and high… read more here.
Keywords: host defense; defense peptides; hdps; resistance ... See more keywords
Transcriptional regulation of human defense peptides: a new direction in infection control
Sign Up to like & getrecommendations! Published in 2018 at "Biological Chemistry"
DOI: 10.1515/hsz-2018-0182
Abstract: Abstract While antibiotics remain as a major therapy against life threatening pathogenic infections, they often lead to side effects like rashes, gastrointestinal and central nervous system reactions to serious allergies or organ damage. These adverse… read more here.
Keywords: defense; defense peptides; infection; regulation human ... See more keywords
Natural amphibian-derived host defense peptides: Peptide immunomodulators with potential therapeutic value.
Sign Up to like & getrecommendations! Published in 2023 at "Protein and peptide letters"
DOI: 10.2174/0929866530666230525163307
Abstract: Due to the rapid evolution of bacterial drug resistance, anti-infective treatment has become a global problem. Therefore, there is an urgent need to develop alternative treatment strategies. Host defense peptides (HDPs) are important components of… read more here.
Keywords: derived host; host defense; defense peptides; amphibian derived ... See more keywords