Multi-omic and comparative analyses revealed monocyte-derived alpha-defensin-1 correlated with COVID-19 severity and inhibited SARS-CoV-2 infection.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medical virology"
DOI: 10.1002/jmv.28845
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological pathogen of coronavirus disease 2019 (COVID-19), a highly contagious disease, spreading quickly and threatening global public health. The symptoms of COVID-19 vary from mild reactions… read more here.
Keywords: multi omic; defensin; infection; severity ... See more keywords
Defensins defend against bone loss
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1597-2
Abstract: Defensins are small, cysteine-rich cationic proteins contained within cells of the immune system. The defensin peptides assist in killing phagocytosed bacteria in neutrophils and in many epithelial cell types. Most defensins function by binding to… read more here.
Keywords: defensins defend; defensin; cramp; bone ... See more keywords
Diagnostic accuracy of alpha-defensin in periprosthetic joint infection: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2017 at "International Orthopaedics"
DOI: 10.1007/s00264-017-3647-3
Abstract: BackgroundAlpha-defensin, a novel biomarker, has shown great potential for the accurate diagnosis of periprosthetic joint infection (PJI) in recent years: many published studies have presented encouraging results. Nevertheless, the diagnostic accuracy of alpha-defensin is inconsistent… read more here.
Keywords: defensin; analysis; diagnostic accuracy; joint infection ... See more keywords
Key Role of Disulfide Bridges in the Antimicrobial Activity of Beta-Defensin from Olive Flounder
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-019-09837-z
Abstract: Proteins that contain multiple disulfide bonds (SS bonds) expressed in Escherichia coli are usually problematic. This study reports the successful recombinant expression of the antimicrobial peptide β-defensin isolated from olive flounder in E. coli .… read more here.
Keywords: defensin; olive flounder; beta defensin; spectroscopy ... See more keywords
Nano Defensin: A Promising Antibacterial Agent Against Colorectal Cancer Related Bacteria
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-021-10237-5
Abstract: Colorectal cancer (CRC) is one of the most common causes of cancer death in the world. Although genes are considered the most important causes that contribute to CRC, intestinal microorganisms are an important player. It… read more here.
Keywords: antibacterial agent; colorectal cancer; defensin; nano defensin ... See more keywords
Differential activity on trypanosomatid parasites of a novel recombinant defensin type 1 from the insect Triatoma (Meccus) pallidipennis.
Sign Up to like & getrecommendations! Published in 2021 at "Insect biochemistry and molecular biology"
DOI: 10.1016/j.ibmb.2021.103673
Abstract: Defensins are one of the major families of antimicrobial peptides (AMPs) that are widely distributed in insects. In Triatomines (Hemiptera: Reduviidae) vectors of Trypanosoma cruzi the causative agent of Chagas disease, two large groups of… read more here.
Keywords: triatoma meccus; meccus pallidipennis; defensin; recombinant defensin ... See more keywords
Ion channel modulation by scorpion hemolymph and its defensin ingredients highlights origin of neurotoxins in telson formed in Paleozoic scorpions.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.01.133
Abstract: An increasing number of scorpion fossils indicate that the venomous telson developed from the sharp telson in sea scorpions into the extant scorpion-like telson in aquatic scorpions in the Paleozoic Era and then further evolved… read more here.
Keywords: scorpion; kv1 kv1; scorpion hemolymph; telson ... See more keywords
Alpha defensin-1 attenuates surgically induced osteoarthritis in association with promoting M1 to M2 macrophage polarization.
Sign Up to like & getrecommendations! Published in 2021 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2021.04.006
Abstract: OBJECTIVE Macrophages play an important part in the pathogenesis of osteoarthritis (OA). Our objective was to determine the effects of α-defensin-1 on macrophage polarization and consequently OA. METHODS OA synovial tissue and synovial fluid were… read more here.
Keywords: defensin; macrophage polarization; polarization; defensin attenuates ... See more keywords
The truncated human beta-defensin 118 can modulate lipopolysaccharide mediated inflammatory response in RAW264.7 macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Peptides"
DOI: 10.1016/j.peptides.2020.170438
Abstract: The family of human β-defensins consists of small cysteine-rich peptides, which are receiving significant attention due to their antimicrobial activity. The N-terminal cysteine motif of β-defensin is considered to contribute to its biological activity. Human… read more here.
Keywords: defensin; raw264; truncated human; defb118 peptide ... See more keywords
Human β-defensin 3 gene modification promotes the osteogenic differentiation of human periodontal ligament cells and bone repair in periodontitis
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Oral Science"
DOI: 10.1038/s41368-020-0078-6
Abstract: Efforts to control inflammation and achieve better tissue repair in the treatment of periodontitis have been ongoing for years. Human β-defensin 3, a broad-spectrum antimicrobial peptide has been proven to have a variety of biological… read more here.
Keywords: bone repair; human defensin; defensin; defensin gene ... See more keywords
Integrated solid-state NMR and molecular dynamics modeling determines membrane insertion of human β-defensin analog
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DOI: 10.1038/s42003-019-0653-6
Abstract: Human β-defensins (hBD) play central roles in antimicrobial activities against various microorganisms and in immune-regulation. These peptides perturb phospholipid membranes for function, but it is not well understood how defensins approach, insert and finally disrupt… read more here.
Keywords: solid state; defensin; state nmr; human defensin ... See more keywords