Improved survival outcomes and restoration of graft‐vs‐leukemia effect by deferasirox after allogeneic stem cell transplantation in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.1928
Abstract: Deferasirox is an oral iron‐chelating agent having possible antileukemia and immune modulatory effects. Few reports have evaluated deferasirox in the setting of allogeneic hematopoietic stem cell transplantation (allo‐HSCT). We investigated the impact of deferasirox after… read more here.
Keywords: allo hsct; graft; effect; stem cell ... See more keywords
Deferasirox for the treatment of iron overload after allogeneic hematopoietic cell transplantation: multicenter phase I study (KSGCT1302)
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Hematology"
DOI: 10.1007/s12185-017-2396-9
Abstract: The aim of this study was to assess the safety and optimal dose of deferasirox for the treatment of iron overload after allogeneic hematopoietic cell transplantation (HCT). The primary endpoint was the maximum tolerated dose… read more here.
Keywords: iron overload; treatment; deferasirox; study ... See more keywords
Preparation of pH-Responsive Vesicular Deferasirox: Evidence from In Silico, In Vitro, and In Vivo Evaluations
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DOI: 10.1021/acsomega.1c03816
Abstract: pH-sensitive nanocarriers can effectively deliver anticancer drugs to tumors and reduce the adverse effects of conventional chemotherapy. In this light, we prepared a novel pH-responsive deferasirox (DFX)-loaded vesicle and comprehensively performed in silico, in vitro,… read more here.
Keywords: niosomal dfx; vitro vivo; silico vitro; deferasirox ... See more keywords
Tuning the Solid- and Solution-State Fluorescence of the Iron-Chelator Deferasirox.
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DOI: 10.1021/jacs.2c01155
Abstract: Deferasirox, an FDA-approved iron chelator, has gained increasing attention for use in anticancer and antimicrobial applications. Recent efforts by our group led to the identification of this core as an easy-to-visualize aggregation-induced emission platform, or… read more here.
Keywords: iron; emission; deferasirox; iron chelator ... See more keywords
Deferasirox – a rarer cause of Fanconi syndrome
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DOI: 10.1080/20009666.2019.1650592
Abstract: ABSTRACT Deferasirox is a recently approved iron chelator and is widely used to treat iron overload in transfusion-dependent patients. Its once-daily dosing and oral route of administration have made it an appealing alternative to deferoxamine.… read more here.
Keywords: rarer cause; cause fanconi; deferasirox rarer; deferasirox ... See more keywords
Deferasirox-induced urticarial vasculitis in a patient with myelodysplastic syndrome*
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DOI: 10.1590/abd1806-4841.20176688
Abstract: Deferasirox is an iron chelator agent used in the treatment of diseases with iron overload, such as thalassemia and myelodysplastic syndrome. Although the majority of adverse reactions of deferasirox involve gastrointestinal symptoms and increase in… read more here.
Keywords: deferasirox; urticarial vasculitis; myelodysplastic syndrome; deferasirox induced ... See more keywords
Antioxidant Activity of Deferasirox and Its Metal Complexes in Model Systems of Oxidative Damage: Comparison with Deferiprone
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DOI: 10.3390/molecules26165064
Abstract: Deferasirox is an orally active, lipophilic iron chelating drug used on thousands of patients worldwide for the treatment of transfusional iron overload. The essential transition metals iron and copper are the primary catalysts of reactive… read more here.
Keywords: antioxidant activity; deferasirox; oxidative damage; iron ... See more keywords