Randomized, Blinded, Placebo‐ and Positive‐Controlled Crossover Study to Determine the Effect of Deferiprone on the QTc Interval in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.352
Abstract: This study evaluated whether deferiprone, an oral iron chelator, acts to prolong the QT interval. Fifty healthy volunteers received single doses of each of the following: therapeutic dose of deferiprone (33 mg/kg), supratherapeutic dose (50… read more here.
Keywords: qtc interval; deferiprone; study; effect ... See more keywords
Antiplatelet activity of deferiprone through cyclooxygenase-1 inhibition
Sign Up to like & getrecommendations! Published in 2019 at "Platelets"
DOI: 10.1080/09537104.2019.1648782
Abstract: Abstract Thalassemia patients are susceptible to both iron overload and thromboembolism. Deferiprone is an iron chelator that shows an antiplatelet activity and thus may alleviate platelet hyperactivation in thalassemia. Therefore, this study aimed to characterize… read more here.
Keywords: mmol; antiplatelet activity; deferiprone; inhibition ... See more keywords
An evaluation of deferiprone as twice-a-day tablets or in combination therapy for the treatment of transfusional iron overload in thalassemia syndromes
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2023.2178409
Abstract: ABSTRACT Introduction Regular blood transfusions in patients with thalassemia syndromes can cause iron overload resulting in complications including cirrhosis, heart problems, or endocrine abnormalities. To prevent iron overload toxicity in these patients, three iron chelators… read more here.
Keywords: thalassemia syndromes; iron overload; transfusional iron; iron ... See more keywords
Prevention of adhesions post-abdominal surgery: Assessing the safety and efficacy of Chitogel with Deferiprone in a rat model
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DOI: 10.1371/journal.pone.0244503
Abstract: Introduction Adhesions are often considered to be an inevitable consequence of abdominal and pelvic surgery, jeopardizing the medium and long-term success of these procedures. Numerous strategies have been tested to reduce adhesion formation, however, to… read more here.
Keywords: abdominal surgery; deferiprone; chitogel deferiprone; adhesion ... See more keywords
Long-term safety of deferiprone treatment in children from the Mediterranean region with beta-thalassemia major: the DEEP-3 multi-center observational safety study
Sign Up to like & getrecommendations! Published in 2018 at "Haematologica"
DOI: 10.3324/haematol.2017.176065
Abstract: Early iron chelation therapy is fundamental in the treatment of b-thalassemia major (b-TM) to avoid the adverse effects of chronic transfusional iron overload. Deferiprone (DFP) was the first oral iron chelator, but remains second line… read more here.
Keywords: deferiprone; safety; thalassemia major; study ... See more keywords
A Multi-Technique Investigation of the Complex Formation Equilibria between Bis-Deferiprone Derivatives and Oxidovanadium (IV)
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DOI: 10.3390/molecules27051555
Abstract: The increasing biomedical interest in high-stability oxidovanadium(IV) complexes with hydroxypyridinone ligands leads us to investigate the complex formation equilibria of VIVO2+ ion with a tetradentate ligand, named KC21, which contains two 3-hydroxy-1,2-dimethylpyridin-4(1H)-one (deferiprone) moieties, and… read more here.
Keywords: complex formation; formation equilibria; multi technique; deferiprone ... See more keywords
Microscale Thermophoresis and Molecular Modelling to Explore the Chelating Drug Transportation in the Milk to Infant
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27144604
Abstract: The microscale thermophoresis (MST) technique was utilized to investigate lactoferrin–drug interaction with the iron chelator, deferiprone, using label-free system. MST depends on the intrinsic fluorescence of one interacting partner. The results indicated a significant interaction… read more here.
Keywords: interaction; microscale thermophoresis; pocket; milk ... See more keywords