Development of Deferoxamine‐Functionalized Cyclodextrin Polymer for Targeted Iron Chelation
Sign Up to like & getrecommendations! Published in 2025 at "ChemistryOpen"
DOI: 10.1002/open.202500186
Abstract: Polymeric systems are used in clinical settings to bind small molecules and ions. They show advantages in pharmacokinetics and reduced side effects compared to low‐molecular‐weight agents. In this study, a cross‐linked β‐cyclodextrin polymer is functionalized… read more here.
Keywords: deferoxamine; iron; cyclodextrin polymer; deferoxamine functionalized ... See more keywords
The effect of deferoxamine injection on composite graft survival in rabbits
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Medicine and Surgery"
DOI: 10.1016/j.amsu.2020.11.029
Abstract: Background Composite graft as a reconstructive therapy option has limitations in size so that it is easily necrotic. Deferoxamine administration has been associated with increased neo-vascularity in wounds. We aimed to compare the administration of… read more here.
Keywords: composite graft; graft; deferoxamine; injection composite ... See more keywords
Deferoxamine deconditioning increases neuronal vulnerability to hemoglobin.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.111926
Abstract: Concomitant treatment with deferoxamine (DFO) protects neural cells from iron and heme-mediated oxidative injury, but also disrupts cell responses to iron loading that may be protective. We hypothesized that DFO treatment and withdrawal would subsequently… read more here.
Keywords: hemoglobin; heme; deferoxamine; vulnerability hemoglobin ... See more keywords
Exploring the potential of repurposed deferoxamine: bridging challenges and novel formulation opportunities.
Sign Up to like & getrecommendations! Published in 2025 at "Nanomedicine"
DOI: 10.1080/17435889.2025.2534318
Abstract: Since the FDA approval of deferoxamine mesylate (Desferal) in 1968, the characteristic low plasma half-life, low plasma protein binding (PB), constrained volume of distribution (Vd), and variety of adverse effects made the dosing, bioavailability, and… read more here.
Keywords: potential repurposed; bridging challenges; deferoxamine; repurposed deferoxamine ... See more keywords
Cost-utility of new film-coated tablet formulation of deferasirox vs deferoxamine among major beta-thalassemia patients in Iran
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DOI: 10.1097/md.0000000000020949
Abstract: Abstract Objectives: Thalassemia is a hereditary disease, which caused economic burden in developing countries. This study evaluated the cost utility of new formulation of deferasirox (Jadenu) vs deferoxamine (Desferal) among B-Thalassemia-major patients from payer perspective… read more here.
Keywords: analysis; utility new; deferoxamine; cost utility ... See more keywords
Deferoxamine in the management of COVID-19 adult patients admitted to ICU: a prospective observational cohort study
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DOI: 10.1097/ms9.0000000000000392
Abstract: Background: COVID-19 infection is associated with high mortality, and despite extensive studying the scientific society is still working to find a definitive treatment. Some experts postulated a beneficial role of Deferoxamine. Aim: The aim of… read more here.
Keywords: deferoxamine; covid adult; admitted icu; patients admitted ... See more keywords
Comparison of the Hydroxylase Inhibitor Dimethyloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing
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DOI: 10.1097/prs.0000000000003072
Abstract: Background: A hallmark of diabetes mellitus is the breakdown of almost every reparative process in the human body, leading to critical impairments of wound healing. Stabilization and activity of the transcription factor hypoxia-inducible factor (HIF)-1&agr;… read more here.
Keywords: wound healing; deferoxamine; hydroxylase inhibitor; dimethyloxalylglycine ... See more keywords
Targeting Mitochondrial Iron Metabolism Suppresses Tumor Growth and Metastasis by Inducing Mitochondrial Dysfunction and Mitophagy
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DOI: 10.1158/0008-5472.can-20-1628
Abstract: These findings show that targeting the iron chelator deferoxamine to mitochondria impairs mitochondrial respiration and biogenesis of [Fe-S] clusters/heme in cancer cells, which suppresses proliferation and migration and induces cell death. Deferoxamine (DFO) represents a… read more here.
Keywords: cancer cells; deferoxamine; iron; iron metabolism ... See more keywords
Application of Deferoxamine in Tissue Regeneration Attributed to Promoted Angiogenesis
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DOI: 10.3390/molecules29092050
Abstract: Deferoxamine, an iron chelator used to treat diseases caused by excess iron, has had a Food and Drug Administration-approved status for many years. A large number of studies have confirmed that deferoxamine can reduce inflammatory… read more here.
Keywords: deferoxamine; tissue regeneration; application deferoxamine; angiogenesis ... See more keywords
Mechanisms underlying the promotion of functional recovery by deferoxamine after spinal cord injury in rats
Sign Up to like & getrecommendations! Published in 2017 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.208591
Abstract: Deferoxamine, a clinically safe drug used for treating iron overload, also repairs spinal cord injury although the mechanism for this action remains unknown. Here, we determined whether deferoxamine was therapeutic in a rat model of… read more here.
Keywords: cord; deferoxamine; treated rats; cord injury ... See more keywords