SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy.
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DOI: 10.1016/j.yjmcc.2019.01.023
Abstract: Cardiac functionality is dependent on a balanced protein turnover. Accordingly, regulated protein decay is critical to maintain cardiac function. Here we demonstrate that deficiency of SPRED2, an intracellular repressor of ERK-MAPK signaling markedly expressed in… read more here.
Keywords: spred2 deficiency; spred2; impaired autophagy; deficiency elicits ... See more keywords