microRNA‐33‐3p involved in selenium deficiency‐induced apoptosis via targeting ADAM10 in the chicken kidney
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28050
Abstract: Selenium (Se) deficiency induces typical clinical and pathological changes and causes various pathological responses at the molecular level in several different chicken organs; the kidney is one of the target organs of Se deficiency. To… read more here.
Keywords: kidney; apoptosis; chicken kidney; deficiency ... See more keywords
SOD2 deficiency-induced oxidative stress attenuates steroidogenesis in mouse ovarian granulosa cells
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.110888
Abstract: This study investigated the effects of SOD2 (MnSOD)-deficiency-induced excessive oxidative stress on ovarian steroidogenesis in vivo and isolated and cultured granulosa cells using WT and Sod2 ± mice. Basal and 48 h eCG-stimulated plasma progesterone levels were decreased… read more here.
Keywords: granulosa cells; granulosa; sod2 deficiency; oxidative stress ... See more keywords
In vivo AAV delivery of glutathione reductase gene attenuates anti-aging gene klotho deficiency-induced kidney damage
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101692
Abstract: Objective Klotho is an aging-suppressor gene which leads to accelerated aging when disrupted. This study was designed to investigate whether glutathione reductase (GR), a critical intracellular antioxidant enzyme, is involved in the pathogenesis of kidney… read more here.
Keywords: kidney; klotho deficiency; gene; glutathione ... See more keywords
Exogenous application of proline alleviates B-deficiency-induced injury while aggravates aluminum toxicity in trifoliate orange seedlings
Sign Up to like & getrecommendations! Published in 2020 at "Scientia Horticulturae"
DOI: 10.1016/j.scienta.2020.109372
Abstract: Abstract Boron (B)-deficiency and aluminum (Al) toxicity are two major factors limiting plant growth. The objective of this study was to investigate the effects of exogenous proline (Pro) on the antioxidant enzyme system and leaf… read more here.
Keywords: aluminum toxicity; proline; deficiency; exogenous proline ... See more keywords
Sulfur deficiency-induced genes affect seed protein accumulation and composition under sulfate deprivation.
Sign Up to like & getrecommendations! Published in 2021 at "Plant physiology"
DOI: 10.1093/plphys/kiab386
Abstract: Sulfur deficiency-induced proteins SDI1 and SDI2 play a fundamental role in sulfur homeostasis under sulfate-deprived conditions (-S) by downregulating glucosinolates. Here, we identified that besides glucosinolate regulation under -S, SDI1 downregulates another sulfur pool, the… read more here.
Keywords: seed; seed storage; sulfur deficiency; storage proteins ... See more keywords
Glucose‐6‐phosphate dehydrogenase deficiency induced haemolysis in a woman with newly diagnosed diabetes after normalisation of hyperglycaemia
Sign Up to like & getrecommendations! Published in 2017 at "Diabetic Medicine"
DOI: 10.1111/dme.13385
Abstract: The association between diabetes and G6PD deficiency is still a matter of debate. Hemolysis due to G6PD deficiency in people with diabetes has been reported, but is uncommon. To date, twenty‐three cases have been reported… read more here.
Keywords: induced haemolysis; dehydrogenase deficiency; phosphate dehydrogenase; glucose phosphate ... See more keywords
MicroRNA 379 Regulates Klotho Deficiency–Induced Cardiomyocyte Apoptosis Via Repression of Smurf1
Sign Up to like & getrecommendations! Published in 2021 at "Hypertension"
DOI: 10.1161/hypertensionaha.120.16888
Abstract: Supplemental Digital Content is available in the text. Klotho is an aging-suppressor gene. Klotho gene deficiency impairs heart function leading to heart failure, but the underlying mechanism remains poorly understood. MicroRNAs are increasingly recognized to… read more here.
Keywords: cardiomyocyte apoptosis; klotho deficiency; apoptosis; deficiency induced ... See more keywords
Vitamin B12 deficiency-induced pseudothrombotic microangiopathy without macrocytosis presenting with acute renal failure: a case report
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Case Reports"
DOI: 10.1186/s13256-018-1815-8
Abstract: BackgroundVitamin B12 deficiency-induced thrombotic microangiopathy, known as pseudothrombotic microangiopathy, is a rare condition which resembles the clinical features of thrombotic thrombocytopenic purpura but requires a markedly different treatment. Most cases of vitamin B12 deficiency have… read more here.
Keywords: microangiopathy; b12 deficiency; vitamin b12; case ... See more keywords
Boldine Ameliorates Estrogen Deficiency-Induced Bone Loss via Inhibiting Bone Resorption
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.01046
Abstract: Osteoporosis is an enormous health problem caused by the imbalance between bone resorption and bone formation. The current therapeutic strategies for osteoporosis still have some limitations. Boldine, an alkaloid isolated from Peumus boldus, has been… read more here.
Keywords: bone; deficiency induced; bone resorption; estrogen deficiency ... See more keywords
High Doses of Bupleurum falcatum Partially Prevents Estrogen Deficiency-Induced Bone Loss With Anti-osteoclastogenic Activity Due to Enhanced iNOS/NO Signaling
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.01314
Abstract: Background and Objective: Bupleurum falcatum (BF) extract, a natural product with anti-inflammatory properties, has been traditionally used to treat menopausal symptoms, but its role in osteoporosis, another serious health concern of menopausal women, remains unknown.… read more here.
Keywords: induced bone; anti; estrogen deficiency; bone loss ... See more keywords
α-Asarone Attenuates Osteoclastogenesis and Prevents Against Oestrogen-Deficiency Induced Osteoporosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.780590
Abstract: Osteoporosis (OP) is defined as low bone mineral density which features over activated osteoclasts (OCs) and bone resorption. Targeting excessive OCs activity is thought to be an effective therapeutic approach for OP treatment. α-asarone (ASA),… read more here.
Keywords: resorption; oestrogen deficiency; bone; osteoclastogenesis ... See more keywords