Zinc deficiency leads to reduced interleukin-2 production by active gene silencing due to enhanced CREMα expression in T cells.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2020.10.052
Abstract: BACKGROUND & AIMS The micronutrient zinc is essential for proper immune function. Consequently, zinc deficiency leads to impaired immune function, as seen in decreased secretion of interleukin (IL)-2 by T cells. Although this association has… read more here.
Keywords: zinc deficiency; deficiency leads; production; expression ... See more keywords
ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation
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DOI: 10.1016/j.isci.2020.101472
Abstract: Summary ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) are secreted metalloproteinases that play a major role in the assembly and degradation of the extracellular matrix (ECM). In this study, we show that ADAMTS18, produced… read more here.
Keywords: deficiency leads; microfibril accumulation; adamts18; adamts18 deficiency ... See more keywords
BRD7 deficiency leads to the development of obesity and hyperglycemia
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DOI: 10.1038/s41598-019-41713-0
Abstract: Obesity is a debilitating disease that has become a global epidemic. Although progress is being made, the underlying molecular mechanism by which obesity develops still remains elusive. Recently, we reported that the expression levels of… read more here.
Keywords: development obesity; brd7; deficiency leads; brd7 deficiency ... See more keywords
Kindlin-3 deficiency leads to impaired erythropoiesis and erythrocyte cytoskeleton
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DOI: 10.1182/bloodadvances.2022008498
Abstract: Key Points • Kindlin-3 promotes EBI formation and regulates erythropoiesis.• By linking to F-actin and spectrin, kindlin-3 maintains the erythrocyte cytoskeleton to support normal erythrocyte shape and deformability. read more here.
Keywords: leads impaired; kindlin deficiency; deficiency leads; impaired erythropoiesis ... See more keywords