PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.08.018
Abstract: Stabilization of stalled replication forks is a prominent mechanism of PARP (Poly(ADP-ribose) Polymerase) inhibitor (PARPi) resistance in BRCA-deficient tumors. Epigenetic mechanisms of replication fork stability are emerging but remain poorly understood. Here, we report the… read more here.
Keywords: mre11 exo1; deficient cells; deficient; fork ... See more keywords
Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor β (RARβ)
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0957-5
Abstract: miR-29b has been identified as a rapamycin-induced microRNA (miRNA) in Tsc2-deficient, mTORC1-hyperactive cells. The biological significance of this induction of miR-29b is unknown. We have found that miR-29b acts as an oncogenic miRNA in Tsc2-deficient… read more here.
Keywords: rar; deficient cells; mir 29b; cell ... See more keywords
PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ATR inhibition in SMARCA4-deficient cells
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02306-1
Abstract: DNA replication stress (RS), a prevalent feature of various malignancies, arises from both genetic mutations and genotoxic exposure. Elevated RS levels increase the vulnerability of cancer cells to ataxia telangiectasia and Rad3-related kinase inhibitors (ATRis).… read more here.
Keywords: replication stress; deficient cells; inhibition; smarca4 deficient ... See more keywords
Stress-induced formation of cell wall-deficient cells in filamentous actinomycetes
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07560-9
Abstract: The cell wall is a shape-defining structure that envelopes almost all bacteria and protects them from environmental stresses. Bacteria can be forced to grow without a cell wall under certain conditions that interfere with cell… read more here.
Keywords: cell wall; wall; deficient cells; wall deficient ... See more keywords
Nuclear deformability increases PARPi sensitivity in BRCA1-deficient cells by increasing microtubule-dependent DNA break mobility
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-60756-8
Abstract: Microtubules and nuclear transmembrane SUN1/2 proteins promote the mobility of DNA Double Strand Breaks (DSBs) induced by ionizing radiation and the misrepair of one-ended DSBs induced in BRCA1-deficient cells by Poly(ADP-ribose) polymerase inhibitors (PARPi). However,… read more here.
Keywords: brca1 deficient; microtubule dependent; deficient cells; mobility ... See more keywords
Peptidoglycan-reshuffling proteins SCO0954, SCO1758, SCO4439, and SCO4440 modulate the formation of wall-deficient cells in Streptomyces coelicolor under hyperosmotic sucrose stress
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-15457-z
Abstract: Streptomycetes are biotechnologically valuable bacteria with complex cell division that produce extracellular vesicles (EVs), typically nanometre-sized but can reach 2.5 μm in diameter. Streptomyces also produce dividing wall-deficient L-forms (0.5–7 μm diameter) and, under hyperosmotic… read more here.
Keywords: wall deficient; deficient cells; hyperosmotic sucrose; formation ... See more keywords
The RPA inhibitor HAMNO sensitizes Fanconi anemia pathway-deficient cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2074200
Abstract: ABSTRACT The Fanconi anemia (FA) DNA repair pathway is required for DNA inter-strand crosslink (ICL) repair. Besides its role in ICL repair, FA proteins play a central role in stabilizing stalled replication forks, thereby ensuring… read more here.
Keywords: rpa inhibitor; hamno; inhibitor hamno; fanconi anemia ... See more keywords
Frequencies of glycosylphosphatidylinositol (GPI)-deficient cells using high-sensitivity flow cytometry as per the 2018 ICCS/ESCCA consensus guideline in patients with hematologic malignancy, aplastic anemia, or cytopenia
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2022.2038561
Abstract: ABSTRACT Objectives We examined the frequencies and sizes of glycosylphosphatidylinositol (GPI)-deficient cells as per the International Clinical Cytometry Society/European Society for Clinical Cell Analysis (ICCS/ESCCA) consensus guidelines for the high-sensitivity detection of GPI-deficient cells. Methods… read more here.
Keywords: gpi deficient; iccs escca; patients hematologic; deficient ... See more keywords
The function of RAD52 N-terminal domain is essential for viability of BRCA-deficient cells
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1145
Abstract: Abstract RAD52 is a member of the homologous recombination pathway that is important for survival of BRCA-deficient cells. Inhibition of RAD52 leads to lethality in BRCA-deficient cells. However, the exact mechanism of how RAD52 contributes… read more here.
Keywords: deficient cells; brca deficient; viability brca; deficient ... See more keywords
Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1173
Abstract: Abstract Cockayne syndrome group B (CSB) protein has been implicated in the repair of a variety of DNA lesions that induce replication stress. However, little is known about its role at stalled replication forks. Here,… read more here.
Keywords: brca1 deficient; csb; fork; deficient cells ... See more keywords
HIRA loss transforms FH-deficient cells
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq8297
Abstract: Fumarate Hydratase (FH) is a mitochondrial enzyme that catalyses the reversible hydration of fumarate to malate in the TCA cycle. Germline mutations of FH lead to HLRCC, a cancer syndrome characterised by a highly aggressive… read more here.
Keywords: loss transforms; hira loss; fh1 deficient; deficient cells ... See more keywords