Prevalence and clinicopathologic/molecular characteristics of mismatch repair-deficient colorectal cancer in the under-50-year-old Japanese population
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DOI: 10.1007/s00595-017-1486-x
Abstract: PurposeTo clarify the prevalence and clinicopathologic/molecular characteristics of mismatch repair (MMR)-deficient colorectal cancer in the young Japanese population.MethodsImmunohistochemical analyses for MMR proteins (MLH1, MSH2, MSH6, and PMS2) were performed in formalin-fixed paraffin-embedded sections prepared from… read more here.
Keywords: characteristics mismatch; deficient colorectal; prevalence clinicopathologic; molecular characteristics ... See more keywords
Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer
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DOI: 10.1038/s41588-024-01777-9
Abstract: Mismatch repair (MMR)-deficient cancer evolves through the stepwise erosion of coding homopolymers in target genes. Curiously, the MMR genes MutS homolog 6 (MSH6) and MutS homolog 3 (MSH3) also contain coding homopolymers, and these are… read more here.
Keywords: cancer; mismatch repair; repair; mutation ... See more keywords
Targeting Arachidonic Acid Metabolism Enhances Immunotherapy Efficacy in ARID1A-Deficient Colorectal Cancer
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DOI: 10.1158/0008-5472.can-24-1611
Abstract: The arachidonic acid pathway is a metabolic vulnerability in ARID1A-deficient colorectal cancer that can be targeted with aspirin to suppress tumor growth and enhance sensitivity to immunotherapy, providing a promising therapeutic strategy. read more here.
Keywords: colorectal cancer; cancer; arachidonic acid; deficient colorectal ... See more keywords