Bidirectional tumor/stroma crosstalk promotes metastasis in mesenchymal colorectal cancer
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DOI: 10.1038/s41388-020-1157-z
Abstract: Patients with the mesenchymal subtype colorectal cancer (CRC) have a poor prognosis, in particular patients with stroma-rich tumors and aberrant SMAD4 expression. We hypothesized that interactions between SMAD4-deficient CRC cells and cancer-associated fibroblasts provide a… read more here.
Keywords: crc cells; metastasis; smad4 deficient; crc ... See more keywords