Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1668-3
Abstract: Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood1–3. A subset of gastrointestinal stromal tumours (GISTs) lack canonical kinase mutations but instead have succinate dehydrogenase (SDH) deficiency and global… read more here.
Keywords: deficient gists; topology; oncogenic programs; sdh deficient ... See more keywords
SDHA Germline Mutations in SDH-Deficient GISTs: A Current Update
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14030646
Abstract: Loss of function of the succinate dehydrogenase complex characterizes 20–40% of all KIT/PDGFRA-negative GIST. Approximately half of SDH-deficient GIST patients lack SDHx mutations and are caused by a hypermethylation of the SDHC promoter, which causes… read more here.
Keywords: deficient gists; germline mutations; loss; sdha ... See more keywords