Glomerular galactose‐deficient IgA1 detected in donor‐derived and recurrent IgA nephropathy
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DOI: 10.1111/tri.14009
Abstract: Galactose deficient IgA1 (Gd-IgA1) plays an important role in the pathogenesis of IgA nephropathy (IgAN)1 . Immunofluorescence (IF) staining of KM55, a Gd-IgA1 specific monoclonal antibody, becomes an easy and reliable tool to detect Gd-IgA1… read more here.
Keywords: iga nephropathy; glomerular galactose; iga1; galactose deficient ... See more keywords
ELL2 Is Downregulated and Associated with Galactose-Deficient IgA1 in IgA Nephropathy
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DOI: 10.1155/2019/2407067
Abstract: Background Galactose-deficient IgA1 (Gd-IgA1) is an important causal factor in IgA nephropathy; however, the underlying mechanism for the production of Gd-IgA1 is unknown. The elongation factor for RNA polymerase II (ELL2), which encoded a key… read more here.
Keywords: iga nephropathy; iga1; galactose deficient; expression ... See more keywords
Comprehensive analysis of aberrantly expressed profiles of mRNA and its relationship with serum galactose-deficient IgA1 level in IgA nephropathy
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DOI: 10.1186/s12967-019-2064-3
Abstract: BackgroundImmunoglobulin A nephropathy (IgAN) is the leading cause of end-stage kidney disease. Previous mRNA microarray profiling studies of IgAN revealed inconsistent data. We sought to identify the aberrantly expressed genes and biological pathways by integrating… read more here.
Keywords: analysis; iga1; galactose deficient; aberrantly expressed ... See more keywords
A Randomized, Controlled Trial of Rituximab in IgA Nephropathy with Proteinuria and Renal Dysfunction.
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DOI: 10.1681/asn.2016060640
Abstract: IgA nephropathy frequently leads to progressive CKD. Although interest surrounds use of immunosuppressive agents added to standard therapy, several recent studies have questioned efficacy of these agents. Depleting antibody-producing B cells potentially offers a new… read more here.
Keywords: rituximab; iga nephropathy; trial rituximab; therapy ... See more keywords
Astragaloside IV Inhibits Galactose-Deficient IgA1 Secretion via miR-98-5p in Pediatric IgA Nephropathy
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DOI: 10.3389/fphar.2021.658236
Abstract: Purpose: The factor associated with IgA nephropathy (IgAN) is an abnormality of IgA known as galactose-deficient IgA1 (Gd-IgA1). The purpose of this study was to determine the molecular role played by miRNAs in the formation… read more here.
Keywords: iga nephropathy; mir; iga1; galactose deficient ... See more keywords