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Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy

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0 Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-23442-z

Abstract: Radiotherapy (RT)-induced tumoricidal immunity is severely limited when tumors are well-established. Here, we report that depleting SIRPα on intratumoral macrophages augments efficacy of RT to eliminate otherwise large, treatment-resistant colorectal (MC38) and pancreatic (Pan02 and… read more here.

Keywords: specific cytotoxic; deficient macrophages; intratumoral sirp; sirp deficient ... See more keywords