Dnase1‐deficient mice spontaneously develop a systemic lupus erythematosus‐like disease
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847875
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease that has high morbidity and can result in multi‐organ damage. SLE is characterized by dysregulated activation of T‐ and B‐lymphocytes and the production of autoantibodies directed against… read more here.
Keywords: dnase1 deficient; systemic lupus; lupus erythematosus; disease ... See more keywords
Impaired Peyer's patch development in BOB.1/OBF.1‐deficient mice
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DOI: 10.1002/eji.202048578
Abstract: The transcriptional co-activator BOB.1/OBF.1, originally identified in B cells, plays an essential role for the development and function of B and T lymphocytes. The main characteristic of BOB.1/OBF.1-deficient mice is the absence of germinal center… read more here.
Keywords: obf deficient; bob; bob obf; deficient mice ... See more keywords
NURR1‐deficient mice have age‐ and sex‐specific behavioral phenotypes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25067
Abstract: The transcription factor NURR1 is essential to the generation and maintenance of midbrain dopaminergic (mDA) neurons and its deregulation is involved in the development of dopamine (DA)‐associated brain disorders, such as Parkinson's disease (PD). The… read more here.
Keywords: nurr1 deficient; deficient mice; sex; mice ... See more keywords
Altered Notch Signaling in Developing Molar Teeth of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)-Deficient Mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1146-7
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with neuroprotective and neurotrophic effects. This suggests its influence on the development of teeth, which are, similarly to the nervous system, ectoderm and neural crest derivatives. Our… read more here.
Keywords: deficient mice; pacap; pacap deficient; notch signaling ... See more keywords
Cardiac mitochondrial respiration following a low-carbohydrate, high-fat diet in apolipoprotein E-deficient mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-018-0653-x
Abstract: Low-carbohydrate diets are considered to be an effective approach to weight loss and have, subsequently, grown in popularity. Despite the apparent health benefits that these diets may provide for insulin resistance, hypertension, and dyslipidemia, their… read more here.
Keywords: carbohydrate high; apolipoprotein deficient; high fat; low carbohydrate ... See more keywords
Behavioural characterization of AnkyrinG deficient mice, a model for ANK3 related disorders
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.04.014
Abstract: ABSTRACT ANK3 encodes AnkyrinG (AnkG), a member of the Ankyrin family that is expressed in several different isoforms in many tissues. A unique serine‐rich domain and tail domain in the two largest isoforms of AnkG… read more here.
Keywords: ankyring deficient; mice model; behavioural characterization; model ... See more keywords
TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2018.09.031
Abstract: Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable, nonselective cation channel and a member of the TRP channel superfamily that acts as a sensor of intracellular redox states. TRPM2 is widely distributed in many… read more here.
Keywords: behavioral flexibility; stress; trpm2; trpm2 deficient ... See more keywords
Macrophages from xCT-deficient mice survive under low cysteine/glutathione redox conditions with high oxidative stress
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.04.186
Abstract: Murine macrophages produce a large body of reactive oxygen species and nitric oxide (NO) in response to inflammatory stimuli and confer protection against bacterial infection. xCT transports cystine into cells in combination with glutamate discharge… read more here.
Keywords: macrophages xct; xct deficient; mice survive; xct macrophages ... See more keywords
The increased marginal zone B cells attenuates early inflammatory responses during sepsis in Gpr174 deficient mice.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.106034
Abstract: GPR174 plays a crucial role in immune responses, but the role of GPR174 in the pathological progress of sepsis remains incompletely understood. In this study, we generated a sepsis model by cecal ligation and puncture… read more here.
Keywords: gpr174 deficient; deficient mice; role; responses sepsis ... See more keywords
GW29-e1791 Nicotine promotes atherosclerosis development in apolipoprotein E-deficient mice through alpha 1 nicotinic acetylcholine receptor on RAW264.7 and MOVAS cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.08.217
Abstract: In our study, we investigated whether nicotine promotes the development of atherosclerosis throughout alpha 1 nicotinic acetylcholine receptor in apolipoprotein E-deficient mice .In vitro, we investigated whether the migration and proliferation of VSMC and macrophage… read more here.
Keywords: alpha nicotinic; nicotinic acetylcholine; apolipoprotein deficient; nicotine promotes ... See more keywords
Rab23 deficient mice exhibit lambdoid suture craniosynostosis through aberrant Fgf signaling
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.028
Abstract: Adolescent idiopathic scoliosis (IS), a disease characterized by 3D spinal curvatures, afflicts 3% of children worldwide. However, the underlying developmental basis for this disease has remained unknown. Recently, the teleost fish have emerged as robust… read more here.
Keywords: spinal curves; rab23 deficient; exhibit lambdoid; csf flow ... See more keywords