Holoprosencephaly phenotypes in LRP2 deficient mouse models are strongly modified by genetic background
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.289
Abstract: spite of sequence divergence. We are currently identifying functional transcription factor binding sites in endodermal enhancers in both species to identify conserved upstream regulators shared between Phallusia and Ciona. Taken together our results suggest that… read more here.
Keywords: mouse models; lrp2 deficient; deficient mouse; holoprosencephaly phenotypes ... See more keywords
Inefficient development of syncytiotrophoblasts in the Atp11a-deficient mouse placenta
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2200582119
Abstract: Significance Plasma membranes are composed of a lipid bilayer in which phosphatidylserine (PtdSer) is confined to the inner leaflet by the action of flippase that translocates PtdSer from the outer to inner leaflets. Two P4-ATPases… read more here.
Keywords: mouse placenta; flippase; deficient mouse; atp11a deficient ... See more keywords
Abstract 5190: Systematic immune-profiling of immune-deficient mouse models: A rational to select ideal host for tumor implantation
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5190
Abstract: Preclinical tumor oncology research relies historically on the analysis of mouse or human tumor cell lines implanted onto severely immune-deficient mouse models carrying nude, SCID or Rag mutations on different genetical background (C57Bl/6N, BalbC, NMRI,… read more here.
Keywords: mouse; deficient mouse; immune deficient; immune ... See more keywords