Rho-Associated Kinase 1 (ROCK1) inhibition is Synthetically Lethal with Von Hippel Lindau (VHL) Deficiency in Clear Cell Renal Cell Carcinoma (CC-RCC)
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DOI: 10.1038/onc.2016.272
Abstract: Clear cell renal cell carcinoma (CC-RCC) is the most lethal of all genitourinary cancers. The functional loss of the von Hippel-Lindau (VHL) gene occurs in 90% of CC-RCC, driving cancer progression. The objective of this… read more here.
Keywords: cell; rcc; deficient rcc; vhl deficiency ... See more keywords
Integrated Molecular Characterization of Fumarate Hydratase–deficient Renal Cell Carcinoma
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DOI: 10.1158/1078-0432.ccr-20-3788
Abstract: Purpose: Fumarate hydratase–deficient renal cell carcinoma (FH-deficient RCC) is a rare but lethal subtype of RCC. Little is known about the genomic profile of FH-deficient RCC, and the therapeutic options for advanced disease are limited.… read more here.
Keywords: cell; hydratase deficient; deficient rcc; fumarate hydratase ... See more keywords
Multi-omics analyses and molecular subtypes to provide potential therapeutic implications in fumarate hydratase-deficient renal cell carcinoma.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.4522
Abstract: 4522 Background: Fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) is a rare yet highly lethal kidney cancer. To deepen our understanding of FH-deficient RCC, we conducted a comprehensive integrated genomic study. Methods: A total of… read more here.
Keywords: fumarate hydratase; deficient rcc; deficient renal; hydratase deficient ... See more keywords