Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of lipid research"
DOI: 10.1016/j.jlr.2022.100199
Abstract: In Gaucher disease (GD), the deficiency of glucocerebrosidase (GCase/ GBA1) causes lysosomal accumulation of glucosylceramide (GlcCer), which is partly converted by acid ceramidase (ACase) to glucosylsphingosine (GlcSph) in the lysosome. Chronically elevated blood and tissue… read more here.
Keywords: glcsph; deficient zebrafish; glucocerebrosidase deficient; excessive glcsph ... See more keywords
Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjz053
Abstract: Abstract The endocrine regulatory roles of the hypothalamic–pituitary–adrenocortical axis on anxiety-like behavior and metabolic status have been found throughout animal taxa. However, the precise effects of the balancing adrenal corticosteroid biosynthesis under the influence of… read more here.
Keywords: deficient zebrafish; somatic growth; pomca deficient; deficient ... See more keywords
Generation and Characterization of a CRISPR/Cas9—Induced 3-mst Deficient Zebrafish
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DOI: 10.3390/biom10020317
Abstract: 3-mercaptopyruvate sulfurtransferase (3-MST) is an enzyme capable of synthesizing hydrogen sulfide (H2S) and polysulfides. In spite of its ubiquitous presence in mammalian cells, very few studies have investigated its contribution to homeostasis and disease development,… read more here.
Keywords: induced mst; cas9 induced; deficient zebrafish; mst deficient ... See more keywords
Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish
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DOI: 10.3390/biom8040153
Abstract: Patients with inherited dilated cardiomyopathy (DCM) often suffer from severe heart failure based on impaired cardiac contractility leading to increased morbidity and mortality. Integrin-linked kinase (ILK) as a part of the cardiac mechanical stretch sensor… read more here.
Keywords: deficient zebrafish; pkb phosphorylation; ilk; ilk deficient ... See more keywords