Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus
Sign Up to like & getrecommendations! Published in 2025 at "Acta Neuropathologica"
DOI: 10.1007/s00401-025-02857-8
Abstract: In Alzheimer’s disease (AD), microglia form distinct cellular aggregates that play critical roles in disease progression, including Aβ plaque-associated microglia (PaM) and the newly identified coffin-like microglia (CoM). PaM are closely associated with amyloid-β (Aβ)… read more here.
Keywords: alzheimer disease; microglia aggregates; disease; define distinct ... See more keywords
Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2016.67.5264
Abstract: Purpose Adenoid cystic carcinomas (ACCs) represent a heterogeneous group of chemotherapy refractory tumors, with a subset demonstrating an aggressive phenotype. We investigated the molecular underpinnings of this phenotype and assessed the Notch1 pathway as a… read more here.
Keywords: subgroup; mutations define; notch1 mutations; metastasis ... See more keywords