Mechanically and chemically defined hydrogel matrices for patient-derived colorectal tumor organoid culture.
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DOI: 10.1016/j.biomaterials.2019.119400
Abstract: Patient-derived tumor organoids offer potentially useful models of cancer tissue physiology. Yet, conventional organoid cultures utilize generic matrices that are difficult to tailor for various unique tumor microenvironments. Here, we employ synthetic, enzymatically crosslinked hydrogels… read more here.
Keywords: tumor; mechanically chemically; crc pdx; defined hydrogel ... See more keywords