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Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6949-4_12
Abstract: Over the past several decades, developmental biologists have discovered fundamental mechanisms by which organs form in developing embryos. With this information it is now possible to generate human "organoids" by the stepwise differentiation of human…
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Keywords:
human pluripotent;
pluripotent stem;
definitive endoderm;
stem cells ... See more keywords
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Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9477-9_4
Abstract: We have developed a method to bulk culture definitive endoderm cells generated from human iPSCs which can be stored and differentiated to hepatocytes. Human iPSC-derived definitive endoderm cells were sorted based on the expression of…
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Keywords:
endoderm;
bulk culture;
definitive endoderm;
derived definitive ... See more keywords
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Published in 2022 at "Cell reports"
DOI: 10.2139/ssrn.4099069
Abstract: Transposable elements (TEs) are the major sources of lineage-specific genomic innovation and comprise nearly half of the human genome, but most of their functions remain unclear. Here, we identify that a series of endogenous retroviruses…
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Keywords:
definitive endoderm;
demethylation;
tet1 mediated;
specific rewiring ... See more keywords