Rhodium(I)-Catalyzed Defluorinative Coupling of Boronic Acids with Monofluoroalkenes.
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DOI: 10.1021/acs.orglett.2c02294
Abstract: We herein describe a highly selective Rh(I)-catalyzed defluorinative coupling of boronic acids with (E)-β-monofluoroacrylates. In contrast to previous methods, the trisubstituted (Z)-alkene products were obtained in excellent dr with an inversion of double bond geometry.… read more here.
Keywords: boronic acids; catalyzed defluorinative; defluorinative coupling; coupling boronic ... See more keywords
Chemoselective Thioacylation of Amines Enabled by Synergistic Defluorinative Coupling.
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DOI: 10.1021/acs.orglett.4c02237
Abstract: A mild and chemoselective method for the thioacylation of amines, including amino acids and peptides, using gem-difluoroalkenes and sulfide, is reported. The distinguishing of the different nucleophilic sites (S-site and diverse N-sites) by the chemoselective… read more here.
Keywords: chemoselective thioacylation; synergistic defluorinative; thioacylation amines; amines enabled ... See more keywords