Defluorinative Cyclization of Enamides with Fluoroalkyl Halides Through Two Vicinal C(sp3)─F Bonds Functionalization
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DOI: 10.1002/advs.202404738
Abstract: Introducing distinctive functional groups to expand the structural diversity and improve the intrinsic properties of parent molecules has been an essential pursuit in organic chemistry. By using perfluoroalkyl halide (PFAH) as a nontraditional, readily available,… read more here.
Keywords: cyclization enamides; cyclization; sp3 bonds; defluorinative cyclization ... See more keywords
Controllable Defluorinative Cyclization for Divergent Synthesis of Pyrrolo[2,3-d]pyrimidines and Fluorinated Pyrimidines from β-CF3-1,3-Enynes and Amidine Hydrochlorides.
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DOI: 10.1021/acs.orglett.5c02345
Abstract: This study successfully developed a novel controllable defluorinative cyclization strategy for β-CF3-1,3-enynes, achieving the divergent synthesis of pyrrolo[2,3-d]pyrimidines and fluorinated pyrimidines. The reaction between β-CF3-1,3-enynes and amidine hydrochlorides at a 1:2 molar ratio triggered selective… read more here.
Keywords: pyrrolo; divergent synthesis; defluorinative cyclization; cf3 enynes ... See more keywords