Chemoenzymatic Defucosylation of Therapeutic Antibodies for Enhanced Effector Functions Using Bacterial α-Fucosidases.
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DOI: 10.1007/978-1-4939-8648-4_19
Abstract: Core fucosylation plays a critical role in modulating the effector functions of therapeutic antibodies such as the antibody-dependent cellular cytotoxicity (ADCC) through adversely affecting the affinity of antibodies for Fcγ receptors. Thus, a facile method… read more here.
Keywords: therapeutic antibodies; bacterial fucosidases; herceptin; effector functions ... See more keywords