Adiponectin Downregulates TNF-&agr; Expression in Degenerated Intervertebral Discs
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DOI: 10.1097/brs.0000000000002364
Abstract: Study Design. Given the results of previous in vitro investigations of the expression patterns of adiponectin and its receptors in healthy and degenerated intervertebral discs (IVDs), we studied the effects of adiponectin on tumor necrosis… read more here.
Keywords: ivd tissues; tnf agr; degenerated intervertebral; expression ... See more keywords
A High Body Mass Index and the Vacuum Phenomenon Upregulate Pain-Related Molecules in Human Degenerated Intervertebral Discs
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DOI: 10.3390/ijms23062973
Abstract: Animal studies suggest that pain-related-molecule upregulation in degenerated intervertebral discs (IVDs) potentially leads to low back pain (LBP). We hypothesized that IVD mechanical stress and axial loading contribute to discogenic LBP’s pathomechanism. This study aimed… read more here.
Keywords: index; degenerated intervertebral; pain related; pain ... See more keywords
Detection of O-Linked-N-Acetylglucosamine Modification and Its Associated Enzymes in Human Degenerated Intervertebral Discs
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DOI: 10.4184/asj.2017.11.6.863
Abstract: Study Design Human herniated discs were obtained from discectomy specimens for the immunohistochemical detection of O-GlcNAc and O-GlcNAcase (OGA)/O-GlcNAc transferase (OGT). Purpose This study aimed to quantify the extent of O-GlcNAcylation and its associated enzymes… read more here.
Keywords: glcnacylation; associated enzymes; degenerated intervertebral; human degenerated ... See more keywords