Intravenous Multifunctional Nanotherapy for Treating Dry Age‐Related Macular Degeneration
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202502925
Abstract: Retinal pigment epithelium (RPE) degeneration is the pathological hallmark of multifactorial dry age‐related macular degeneration (dAMD). Mounting evidence implicates oxidative stress and aberrant activation of mammalian target of rapamycin (mTOR) as key drivers of this… read more here.
Keywords: related macular; degeneration; age related; dry age ... See more keywords
Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202104888
Abstract: Intervertebral disc degeneration (IDD) results from the dysfunction of nucleus pulposus (NP) cells and the exhaustion of NP progenitors (ProNPs). The cellular applications of NP cells during IDD are currently limited due to the lack… read more here.
Keywords: pronps; degeneration; nucleus pulposus; intervertebral disc ... See more keywords
Sirt6 Mono‐ADP‐Ribosylates YY1 to Promote Dystrophin Expression for Neuromuscular Transmission
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202406390
Abstract: The degeneration of the neuromuscular junction (NMJ) and the decline in motor function are common features of aging, but the underlying mechanisms have remained largely unclear. This study reveals that Sirt6 is reduced in aged… read more here.
Keywords: nmj degeneration; adp ribosylates; degeneration; neuromuscular transmission ... See more keywords
Quantitative muscle ultrasound is useful for evaluating secondary axonal degeneration in chronic inflammatory demyelinating polyneuropathy
Sign Up to like & getrecommendations! Published in 2017 at "Brain and Behavior"
DOI: 10.1002/brb3.812
Abstract: In chronic inflammatory demyelinating polyneuropathy (CIDP), exclusion of secondary axonal degeneration is challenging with conventional methods such as nerve conduction study (NCS), needle electromyography, and nerve biopsy. Increased echo intensity (EI) and decreased muscle thickness… read more here.
Keywords: inflammatory demyelinating; muscle; chronic inflammatory; axonal degeneration ... See more keywords
The dentato–rubro–olivary pathway revisited: New MR imaging observations regarding hypertrophic olivary degeneration
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Anatomy"
DOI: 10.1002/ca.22866
Abstract: Hypertrophic olivary degeneration (HOD) following a lesion of the dentato–rubro–olivary pathway (DROP) is a well‐known imaging finding and has extensively been described in the recent literature. We reviewed our patients with HOD as a result… read more here.
Keywords: olivary degeneration; degeneration; dentato rubro; rubro olivary ... See more keywords
Fat mass and obesity‐associated protein alleviates Aβ1–40 induced retinal pigment epithelial cells degeneration via PKA/CREB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11959
Abstract: Amyloid‐β (Aβ) is thought to be a critical pathologic factor of retinal pigment epithelium (RPE) degeneration in age‐related macular degeneration (AMD). Aβ induces inflammatory responses in RPE cells and recent studies demonstrate the N6‐methyladenosine (m6A)… read more here.
Keywords: degeneration; pka; rpe degeneration; retinal pigment ... See more keywords
Fluid-structure interaction analysis of transcatheter aortic valve implantation.
Sign Up to like & getrecommendations! Published in 2023 at "International journal for numerical methods in biomedical engineering"
DOI: 10.1002/cnm.3704
Abstract: Transcatheter aortic valve implantation (TAVI) is a minimally invasive intervention for the treatment of severe aortic valve stenosis. The main cause of failure is the structural deterioration of the implanted prosthetic leaflets, possibly inducing a… read more here.
Keywords: aortic valve; degeneration; valve implantation; transcatheter aortic ... See more keywords
Understanding embryonic development for cell‐based therapies of intervertebral disc degeneration: Toward an effort to treat disc degeneration subphenotypes
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Dynamics"
DOI: 10.1002/dvdy.217
Abstract: Chronic low back and neck pain are associated with intervertebral disc degeneration and are major contributors to the global burden of disability. New evidence now suggests that disc degeneration comprises a spectrum of subphenotypes influenced… read more here.
Keywords: based therapies; degeneration; cell based; intervertebral disc ... See more keywords
Müller glial cell reactivation in Xenopus models of retinal degeneration
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DOI: 10.1002/glia.23165
Abstract: A striking aspect of tissue regeneration is its uneven distribution among different animal classes, both in terms of modalities and efficiency. The retina does not escape the rule, exhibiting extraordinary self‐repair properties in anamniote species… read more here.
Keywords: glial cell; cell reactivation; ller glial; cell ... See more keywords
Electrical stimulation accelerates Wallerian degeneration and promotes nerve regeneration after sciatic nerve injury
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24309
Abstract: Following peripheral nerve injury (PNI), Wallerian degeneration (WD) in the distal stump can generate a microenvironment favorable for nerve regeneration. Brief low‐frequency electrical stimulation (ES) is an effective treatment for PNI, but the mechanism underlying… read more here.
Keywords: nerve injury; regeneration; degeneration; nerve regeneration ... See more keywords
Network spread determines severity of degeneration and disconnection in Huntington's disease
Sign Up to like & getrecommendations! Published in 2019 at "Human Brain Mapping"
DOI: 10.1002/hbm.24695
Abstract: Trans‐neuronal propagation of mutant huntingtin protein contributes to the organised spread of cortico‐striatal degeneration and disconnection in Huntington's disease (HD). We investigated whether the network diffusion model, which models transneuronal spread as diffusion of pathological… read more here.
Keywords: degeneration disconnection; huntington disease; disconnection; brain ... See more keywords