Ionizable Coenzyme-Engineered Lipid/Fiber Microplexes Boost Ribosomal Translation to Improve mRNA Therapy for Degenerative Diseases.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced materials"
DOI: 10.1002/adma.202513720
Abstract: Mitochondrial dysfunction‐mediated ribosomal translation suppression is a hallmark of aging and a major driver of degenerative diseases, limiting mRNA therapy efficacy. Here, ionizable coenzyme Q10 (iCoQ10)‐engineered lipid/fiber microplexes (iCLNP@SF) are developed that restore the mitochondrial‐ribosomal… read more here.
Keywords: mrna; degenerative diseases; translation; mrna therapy ... See more keywords
The impact of routine whole spine MRI screening in the evaluation of spinal degenerative diseases
Sign Up to like & getrecommendations! Published in 2017 at "European Spine Journal"
DOI: 10.1007/s00586-017-4944-7
Abstract: PurposeMagnetic resonance imaging (MRI) of the spine is a sensitive investigation, which not only provides detailed images of the spinal column but also adjacent spinal regions and para-vertebral organ systems. Such incidental findings (IF) can… read more here.
Keywords: degenerative diseases; group; whole spine; mri ... See more keywords
The role of efferocytosis in neuro-degenerative diseases
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Sciences"
DOI: 10.1007/s10072-021-05835-6
Abstract: Efferocytosis has a critical role in maintaining tissues and organs’ homeostasis by removing apoptotic cells. It is essential for human health, and disturbances in efferocytosis may result indifferent illnesses. In case of inadequate clearance of… read more here.
Keywords: efferocytosis neuro; neuro degenerative; degenerative diseases; role efferocytosis ... See more keywords
Melatonin, an ubiquitous metabolic regulator: functions, mechanisms and effects on circadian disruption and degenerative diseases
Sign Up to like & getrecommendations! Published in 2020 at "Reviews in Endocrine and Metabolic Disorders"
DOI: 10.1007/s11154-020-09570-9
Abstract: The last four decades, we assist to an increasing scientific interest on melatonin, a circadian hormone, a metabolic regulator which influences not only plants’ metabolism and their defense against pathogens but mostly the animals and… read more here.
Keywords: metabolic regulator; diseases melatonin; circadian disruption; degenerative diseases ... See more keywords
Reliability of diagnostic imaging for degenerative diseases with osseous changes in the temporomandibular joint with special emphasis on subchondral cyst
Sign Up to like & getrecommendations! Published in 2019 at "Oral Radiology"
DOI: 10.1007/s11282-019-00392-3
Abstract: Objectives The present study aimed to clarify the reliabilities of four characteristic appearances, subchondral cyst, erosion, generalized sclerosis, and osteophyte, for evaluation of degenerative diseases with osseous changes in the temporomandibular joint (TMJ) using panoramic… read more here.
Keywords: subchondral cyst; degenerative diseases; changes temporomandibular; diseases osseous ... See more keywords
Nanotechnological approach and bio-inspired materials to face degenerative diseases in aging
Sign Up to like & getrecommendations! Published in 2019 at "Aging Clinical and Experimental Research"
DOI: 10.1007/s40520-019-01365-6
Abstract: The aging of the world population is increasingly claimed as an alarming situation, since an ever-raising number of persons in advanced age but still physically active is expected to suffer from invalidating and degenerative diseases.… read more here.
Keywords: degenerative diseases; materials face; bio inspired; nanotechnological approach ... See more keywords
Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
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DOI: 10.1038/s41467-017-02395-2
Abstract: Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old. Nevertheless, it has remained unclear to what extent molecular signatures of ageing reflect this… read more here.
Keywords: shift; degenerative diseases; epidemiology; ageing reflect ... See more keywords
iPSC-derived retinal pigment epithelium: an in vitro platform to reproduce key cellular phenotypes and pathophysiology of retinal degenerative diseases.
Sign Up to like & getrecommendations! Published in 2024 at "Stem cells translational medicine"
DOI: 10.1093/stcltm/szae097
Abstract: Retinal pigment epithelium (RPE) atrophy is a significant cause of human blindness worldwide, occurring in polygenic diseases such as age-related macular degeneration (AMD) and monogenic diseases such as Stargardt diseases (STGD1) and late-onset retinal degeneration… read more here.
Keywords: retinal degenerative; rpe; pigment epithelium; retinal pigment ... See more keywords
Comparison of Endoscopic and Minimally Invasive Transforaminal Lumbar Interbody Fusion for Lumbar Degenerative Diseases: A Meta-analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical spine surgery"
DOI: 10.1097/bsd.0000000000001428
Abstract: STUDY DESIGN Systematic review and meta-analysis. OBJECTIVE To compare the results of endoscopic transforaminal lumbar interbody fusion (Endo-TLIF) and minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) for patients with lumbar degenerative diseases. SUMMARY OF BACKGROUND… read more here.
Keywords: lumbar; degenerative diseases; fusion; tlif ... See more keywords
An Engineering Platform for Clinical Application of Optogenetic Therapy in Retinal Degenerative Diseases
Sign Up to like & getrecommendations! Published in 2023 at "IEEE Journal of Translational Engineering in Health and Medicine"
DOI: 10.1109/jtehm.2023.3275103
Abstract: Optogenetics is a new approach for controlling neural circuits with numerous applications in both basic and clinical science. In retinal degenerative diseases, the photoreceptors die, but inner retinal cells remain largely intact. By expressing light… read more here.
Keywords: degenerative diseases; retinal degenerative; engineering platform; therapy ... See more keywords
On the potential therapeutic role of taurine in retinal degenerative diseases
Sign Up to like & getrecommendations! Published in 2024 at "Acta Ophthalmologica"
DOI: 10.1111/aos.16332
Abstract: Taurine, considered a non‐essential amino acid that differs from other amino acids in that it contains a sulfonic acid instead of a carboxyl group, is the most abundant amino acid in the retina. Taurine plays… read more here.
Keywords: taurine; retinal degenerative; degeneration; degenerative diseases ... See more keywords