PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Triggers Vascular Smooth Muscle Cell Senescence and Apoptosis: Implication of Its Direct Role in Degenerative Vascular Disease
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.316902
Abstract: Supplemental Digital Content is available in the text. Objective: PCSK9 (proprotein convertase subtilisin/kexin type 9) plays a critical role in cholesterol metabolism via the PCSK9–LDLR (low-density lipoprotein receptor) axis in the liver; however, evidence indicates… read more here.
Keywords: pcsk9; pcsk9 proprotein; degenerative vascular; smooth muscle ... See more keywords
Dysregulation of Calpain Proteolytic Systems Underlies Degenerative Vascular Disorders
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Atherosclerosis and Thrombosis"
DOI: 10.5551/jat.rv17008
Abstract: Chronic vascular diseases such as atherosclerosis, aneurysms, diabetic angiopathy/retinopathy as well as fibrotic and proliferative vascular diseases are generally complicated by the progression of degenerative insults, which are characterized by endothelial dysfunction, apoptotic/necrotic cell death… read more here.
Keywords: vascular disorders; calpain; calpain proteolytic; cell ... See more keywords