Risk of hypoglycaemia with insulin degludec versus insulin glargine U300 in insulin-treated patients with type 2 diabetes: the randomised, head-to-head CONCLUDE trial
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DOI: 10.1007/s00125-019-05080-9
Abstract: Aims/hypothesis A head-to-head randomised trial was conducted to evaluate hypoglycaemia safety with insulin degludec 200 U/ml (degludec U200) and insulin glargine 300 U/ml (glargine U300) in individuals with type 2 diabetes treated with basal insulin. Methods This… read more here.
Keywords: insulin; trial; hypoglycaemia; degludec ... See more keywords
Switching from Glargine to Degludec is not associated with an overt change in glucose control in a cohort of patients with type 1 diabetes: a CGM analysis
Sign Up to like & getrecommendations! Published in 2018 at "Acta Diabetologica"
DOI: 10.1007/s00592-018-1121-3
Abstract: After DCCT, intensive multiple daily insulin injections protocol became the standard therapy for patients with T1DM intended to maintain a lower HbA1c without hypoglycemia and thus to decrease the risk of microvascular complications. Design and… read more here.
Keywords: insulin; hypoglycemia; switching glargine; glargine degludec ... See more keywords
Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial
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DOI: 10.1016/s0140-6736(21)01443-4
Abstract: BACKGROUND Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide and GLP-1 receptor agonist under development for the treatment of type 2 diabetes. We aimed to assess the efficacy and safety of tirzepatide versus titrated insulin… read more here.
Keywords: degludec; tirzepatide versus; hba1c; insulin degludec ... See more keywords
Insulin degludec in the first trimester of pregnancy: Report of two cases
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DOI: 10.1111/jdi.12721
Abstract: Insulin degludec is an extra‐long‐acting insulin analog that allows for enhanced efficacy and flexibility in the injection time. However, it is not approved for use during pregnancy. We report the pregnancy outcome and newborn conditions… read more here.
Keywords: degludec treatment; pregnancy; pregnancy report; degludec ... See more keywords
The rate of hyperglycemia and ketosis with insulin degludec‐based treatment compared with insulin detemir in pediatric patients with type 1 diabetes: An analysis of data from two randomized trials
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DOI: 10.1111/pedi.12821
Abstract: Historically, data on the rate of hyperglycemia and ketosis have not been collected in clinical trials. However, it is clinically important to assess the rate of these events in children with type 1 diabetes (T1D).… read more here.
Keywords: insulin; hyperglycemia ketosis; type diabetes; rate ... See more keywords
United States experience of insulin degludec alone or in combination for type 1 and type 2 diabetes
Sign Up to like & getrecommendations! Published in 2017 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s132581
Abstract: Insulin degludec has been the product of a sophisticated and systematic biochemical engineering program which began with the release of insulin detemir. The goal was to produce a long-lasting basal insulin with low individual variability.… read more here.
Keywords: insulin; glargine; type diabetes; degludec alone ... See more keywords
Use of Insulin Degludec in Type 1 Diabetes Clinical Practice in the U.K.—General Practice Data from Two English Regions and Data from the Association of British Clinical Diabetologists (ABCD) Nationwide Degludec Audit
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DOI: 10.2337/db18-2291-pub
Abstract: In clinical trials insulin degludec (Tresiba) was associated with less hypoglycaemia and less day to day glucose variability than older basal insulins. This study assessed the use of insulin degludec in type 1 diabetes in… read more here.
Keywords: hba1c; type diabetes; practice; degludec ... See more keywords
Comparison of Insulins Glargine and Degludec in Diabetic Rhesus Macaques (Macaca mulatta) with CGM Devices.
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DOI: 10.30802/aalas-cm-20-000075
Abstract: Treating and monitoring type 2 diabetes mellitus (T2DM) in NHP can be challenging. Multiple insulin and hypoglycemictherapies and management tools exist, but few studies demonstrate their benefits in a NHP clinical setting. The insulins glargine… read more here.
Keywords: degludec; chemistry; rhesus macaques; diabetic rhesus ... See more keywords