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   Articles with "degradation" as a keyword



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Hsp70 – a master regulator in protein degradation

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recommendations! Published in 2017 at "FEBS Letters"

DOI: 10.1002/1873-3468.12751

Abstract: Proteostasis, the controlled balance of protein synthesis, folding, assembly, trafficking and degradation, is a paramount necessity for cell homeostasis. Impaired proteostasis is a hallmark of ageing and of many human diseases. Molecular chaperones are essential… read more here.

Keywords: protein; degradation; hsp70 master; protein degradation ... See more keywords
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Voltage‐gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation

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recommendations! Published in 2019 at "FEBS Letters"

DOI: 10.1002/1873-3468.13641

Abstract: The voltage‐gated sodium channels (VGSCs) are aberrantly expressed in a variety of tumors and play an important role in tumor growth and metastasis. Here, we show that VGSCs auxiliary β3 subunit, encoded by the SCN3B… read more here.

Keywords: degradation; p53 degradation; p53; gated sodium ... See more keywords
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The BRCA2 and CDKN1A‐interacting protein (BCCIP) stabilizes stalled replication forks and prevents degradation of nascent DNA

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14406

Abstract: DNA replication stress is characterized by impaired replication fork progression, causing some of the replication forks to collapse and form DNA breaks. It is a primary cause of genomic instability leading to oncogenic transformation. The… read more here.

Keywords: bccip; dna; nascent dna; replication ... See more keywords

Diacylglycerol kinase alleviates autophagic degradation of the endoplasmic reticulum in SPT10‐deficient yeast to enhance triterpene biosynthesis

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14418

Abstract: A recent study showed that deletion of the gene encoding the transcription regulator SuPpressor of Ty10 (SPT10) increases total phospholipids, and our previous study established a critical link between phospholipids and the mevalonate/ergosterol (MEV/ERG) pathway,… read more here.

Keywords: endoplasmic reticulum; triterpene; spt10; spt10 yeast ... See more keywords
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Transcription factor Atf1‐dependent degradation of the mitotic cyclin Cdc13 is regulated by multiple factors in Schizosaccharomyces pombe

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14439

Abstract: The bZIP transcription factor Atf1 is a key player in the transcriptional programme of Schizosaccharomyces pombe cell cycle. It also controls both expression and degradation of mitotic cyclin Cdc13. Temporal regulation of these opposing functions of… read more here.

Keywords: degradation mitotic; mitotic cyclin; factor atf1; schizosaccharomyces pombe ... See more keywords
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CCDC115 inhibits autophagy‐mediated degradation of YAP to promote cell proliferation

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recommendations! Published in 2023 at "FEBS Letters"

DOI: 10.1002/1873-3468.14575

Abstract: Autophagy and Hippo signalling pathways both play important roles in cell homeostasis and are often involved in tumourigenesis. However, the crosstalk between these two signal pathways in response to stress conditions, such as nutrient deficiency,… read more here.

Keywords: cell proliferation; inhibits autophagy; yap; ccdc115 inhibits ... See more keywords
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ER-to-Lysosome Associated Degradation (ERLAD) in a Nutshell: mammalian, yeast and plant ER-phagy as induced by misfolded proteins.

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recommendations! Published in 2023 at "FEBS letters"

DOI: 10.1002/1873-3468.14674

Abstract: Conserved catabolic pathways operate to remove aberrant polypeptides from the endoplasmic reticulum (ER), the major biosynthetic organelle of eukaryotic cells. The best known are the ER-associated degradation (ERAD) pathways that control retro-translocation of terminally misfolded… read more here.

Keywords: lysosome associated; associated degradation; mammalian yeast; misfolded proteins ... See more keywords
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The PI3K/mTOR dual inhibitor NVP‐BEZ235 stimulates mutant p53 degradation to exert anti‐tumor effects on triple‐negative breast cancer cells

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recommendations! Published in 2020 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12806

Abstract: Nearly half of human cancers harbor p53 mutations, and mutant p53 (mutp53) promotes carcinogenesis, metastasis, tumor recurrence and chemoresistance. mutp53 is observed in 30% of breast carcinomas, including triple‐negative breast cancer (TNBC), and thus mutp53… read more here.

Keywords: degradation; bez235; tnbc; mutant p53 ... See more keywords
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Potential proton and photon dose degradation in advanced head and neck cancer patients by intratherapy changes

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recommendations! Published in 2017 at "Journal of Applied Clinical Medical Physics"

DOI: 10.1002/acm2.12189

Abstract: Abstract Purpose Evaluation of dose degradation by anatomic changes for head‐and‐neck cancer (HNC) intensity‐modulated proton therapy (IMPT) relative to intensity‐modulated photon therapy (IMRT) and identification of potential indicators for IMPT treatment plan adaptation. Methods For… read more here.

Keywords: degradation; impt; dose degradation; target ... See more keywords
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Effects of Dy Addition on the Mechanical and Degradation Properties of Mg–2Zn–0.5Zr Alloy

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recommendations! Published in 2020 at "Advanced Engineering Materials"

DOI: 10.1002/adem.201901360

Abstract: As candidates for biomaterials, magnesium and its alloys have promising properties such as biodegradability and biocompatibility. However, their poor mechanical properties and rapid degradation rate limit clinical application; therefore, solving these issues is essential for… read more here.

Keywords: mechanical degradation; microscopy; 2zn 5zr; degradation ... See more keywords
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Enhanced Mechanical and Degradation Properties of Hollow Glass Microspheres/Mg Matrix Composites by Incorporating Copper Power for Degradable Downhole Tool Applications

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recommendations! Published in 2021 at "Advanced Engineering Materials"

DOI: 10.1002/adem.202100615

Abstract: In this work, the effects of Cu addition on the microstructure, mechanical properties, and degradation behavior of the hollow glass microspheres/Mg alloy composites (HGM/MA) are investigated. The results indicate that with the Cu content increases… read more here.

Keywords: hollow glass; glass microspheres; degradation; enhanced mechanical ... See more keywords