Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins.
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DOI: 10.1073/pnas.2119644119
Abstract: SignificanceMissense mutations in the TP53 gene, encoding the p53 tumor suppressor, are very frequent in human cancer. Some of those mutations, particularly the more common ("hotspot") ones, not only abrogate p53's tumor suppressor activities but… read more here.
Keywords: degradation cell; cell adhesion; cancer; cell ... See more keywords