Advances in targeted degradation of endogenous proteins
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03112-6
Abstract: Protein silencing is often employed as a means to aid investigations in protein function and is increasingly desired as a therapeutic approach. Several types of protein silencing methodologies have been developed, including targeting the encoding… read more here.
Keywords: protein; degradation endogenous; degradation; advances targeted ... See more keywords
Harnessing Antibody-Mimetic Selectivity for Activation-State-Specific Targeted Degradation of Endogenous K-Ras
Sign Up to like & getrecommendations! Published in 2021 at "ACS Central Science"
DOI: 10.1021/acscentsci.1c00084
Abstract: The Ras family of GTPases and are important but poorly druggable therapeutic targets that are frequently mutated in cancer. In this issue of ACS Central Science, Lim et al. present the development of a panel… read more here.
Keywords: state; degradation endogenous; degradation; small molecule ... See more keywords