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Proteasomal and lysosomal clearance of faulty secretory proteins: ER-associated degradation (ERAD) and ER-to-lysosome-associated degradation (ERLAD) pathways

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Published in 2019 at "Critical Reviews in Biochemistry and Molecular Biology"

DOI: 10.1080/10409238.2019.1610351

Abstract: Abstract About 40% of the eukaryotic cell’s proteins are inserted co- or post-translationally in the endoplasmic reticulum (ER), where they attain the native structure under the assistance of resident molecular chaperones and folding enzymes. Subsequently,… read more here.

Keywords: degradation; degradation erad; clearance; degradation erlad ... See more keywords